| 张馨,唐相友,宋华莉,石鹏,郝玉徽.蜂产品对放射性损伤的防治研究进展[J].中华放射医学与防护杂志,2020,40(8):648-652 |
| 蜂产品对放射性损伤的防治研究进展 |
| Research progress on radioprotective effects of bee products |
| 投稿时间：2019-10-19 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.08.013 |
| 中文关键词: 辐射防护 氧化应激 细胞凋亡 DNA损伤 |
| 英文关键词:Radioprotection Oxidative stress Apoptosis DNA damage |
| 基金项目:火箭军后勤部应用基础研究项目（CEP17J011）；军队后勤重大项目（AWS7J007） |
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| 中文摘要: |
| 在军事、医疗和公共卫生方面，辐射暴露是一个持续而严重的威胁。针对辐射引起的损伤需要有效的预防或缓解治疗，但是目前这些问题尚未得到解决。临床上少数食品药品监督管理局（FDA）批准的辐射防护剂副作用大，限制其广泛使用。据报道，一些天然的无毒化合物（如蜂产品）可通过减轻辐射引起的氧化应激、细胞凋亡和DNA损伤来预防和治疗辐射引起的口腔黏膜炎、食管炎、皮肤损伤、肝损伤、肠道损伤和造血系统的损伤等。这表明这些蜂产品有作为辐射防护剂的潜力。本文就蜂产品对防治放射性损伤的实验及临床研究进行综述。 |
| 英文摘要: |
| Radiation exposure is an ongoing and serious threat in military and public health concern, and there is an unmet need for effective preventative or mitigative treatment against radiation-induced injuries. The handful of FDA approved radiation protection agents cannot be widely used due to their side effects. Some natural non-toxic compounds such as bee products have been reported to prevent and treat radiation-induced injuries of oral mucosa, esophagus, skin, liver, intestine and hemopoietic system by reducing radiation-induced oxidative stress, apoptosis and DNA damage, indicating that they may be potential options of safe radioprotective agents. In this paper, the experimental and clinical studies on prevention and treatment of radiation injury by bee products were reviewed. |
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