| 杨春勇,周媛媛,曹兴江,等.江苏省8台加速器调强放疗靶体积和危及器官剂量及二维剂量分布验证方法研究[J].中华放射医学与防护杂志,2020,40(2):129-133.Yang Chunyong,Zhou Yuanyuan,Cao Xingjiang,et al.Verification of doses to PTV and OAR and 2D dose distribution in IMRT for 8 accelerators in Jiangsu province[J].Chin J Radiol Med Prot,2020,40(2):129-133 |
| 江苏省8台加速器调强放疗靶体积和危及器官剂量及二维剂量分布验证方法研究 |
| Verification of doses to PTV and OAR and 2D dose distribution in IMRT for 8 accelerators in Jiangsu province |
| 投稿时间：2019-04-02 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.02.010 |
| 中文关键词: 调强放射治疗 免冲洗胶片 靶体积 危及器官 二维剂量分布 |
| 英文关键词:Intensity modulated radiation therapy Radiochromic film Planned target volume Organ at risk Two-dimensional dose distribution |
| 基金项目:IAEA资助项目（CPR/17821）；江苏省流行病学重点学科（ZDXKA2016008）；江苏省医学创新团队（CXTDA2017029） |
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| 中文摘要: |
| 目的 用热释光剂量计（TLD）及免冲洗胶片（film）测量调强放射治疗靶体积（TPV）、危及器官（OAR）剂量和二维剂量分布验证方法。方法 选择8台医用直线加速器（瓦里安、医科达、西门子），国际原子能机构（IAEA）提供的聚苯乙烯专用模体，经CT扫描，影像传给放射治疗计划系统（TPS）制定治疗计划，勾画PTV，OAR的处方剂量，计算相应的监督单位（MU），能量6 MV X射线束，对模体实施调强放疗（IMRT）照射。照射后的TLD和胶片邮寄至中国疾病预防控制中心辐射防护与核安全医学所二级标准剂量学实验室测量和估算。结果 按IAEA要求，对于靶体积和危及器官剂量，TLD测量剂量值与TPS计划剂量值的相对偏差为±7.0%。靶体积结果表明，8台加速器的TLD测量值与TPS计划值的相对偏差为0.6%~5.9%，符合要求。危及器官结果表明，8台加速器的TLD测量值与TPS计划值相对偏差为-0.6%~7.0%，符合要求。按IAEA要求，二维剂量分布3 mm/3%通过率为90%。8台加速器的胶片测量与TPS计划二维剂量分布通过率为90.2%~100.0%，符合要求。结论 用TLD和放射性免冲洗胶片验证调强放射治疗靶体积、危及器官和二维剂量分布通过率，方法可行，可推广大范围运用到质量核查中，也可用于医院内部核查。 |
| 英文摘要: |
| Objective To validate the method for measuring the TPV and OAR doses and 2D dose distribution in IMRT through using TLD and radiochromic film. Methods Eight medical linear accelerators (Valian, Elekta, Siemens) were selected. The polystyrene phantom provided by IAEA was CT scanned and the image obtained was transferred to TPS for formulation of treatment plan, prescription of PTV and OAR doses and calculation of corresponding monitoring unit (MU), IMRT was performed on the phantom using 6 MV X-ray. Irradiated TLDs and films were measured and evaluated at the Secondary Standard Dosimetry Laboratory at the Radiation Safety Institute of Chinese Center for Disease Control and Prevention. Results According to IAEA requirement, the relative deviations between TLD-measured and TPS-planned doses were within±7.0% for the prescribed PTV and OAR doses. As measured result, the PTV values for 8 accelerators were in the range of 0.6% to 5.9%, consistent with the IAEA requirements, whereas the OAT values for 8 accelerators were within -0.6% to 7.0%, consistent the requirements. As IAEA required, the 2D dose distribution passing rate of 3 mm/3% should be higher than 90%. The film-measured and TPS-planned values for 8 accelerators were within 90.2% to 100.0%, consistent with the requirements. Conclusions TLD and radiochromic film are feasible in validating the PTV and OAR doses and the 2D dose distribution pass rate in IMRT. This method can be widely used in quality audit and internal verification in IMRT in medical institutiions on a large scale. |
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