| 田雪蕾,陆雪,封江彬,吕玉民,田梅,刘青杰.放射工作人员外周血淋巴细胞核质桥水平及其影响因素分析[J].中华放射医学与防护杂志,2020,40(2):94-98 |
| 放射工作人员外周血淋巴细胞核质桥水平及其影响因素分析 |
| Influence factors of nucleoplasmic bridge frequencies in the peripheral blood lymphocytes of radiation workers |
| 投稿时间：2019-04-09 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.02.004 |
| 中文关键词: 核质桥 放射工作人员 影响因素 电离辐射 |
| 英文关键词:Nucleoplasmic bridges Radiation worker Influence factors Ionizing radiation |
| 基金项目:国家自然科学基金（81573081） |
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| 中文摘要: |
| 目的 初步探讨放射工作人员的性别、年龄、工龄、工种和年有效剂量等因素对其外周血淋巴细胞核质桥（NPB）的影响。方法 收集100例河南省放射工作人员外周血，利用细胞分裂阻滞实验（CBMN法）制备人外周血淋巴细胞NPB标本，分析NPB率和NPB细胞率及各类因素对NPB的影响。结果 放射工作人员NPB率高于正常健康人群（Z=-8.123，P<0.01）。性别对NPB的影响差异无统计学意义（P>0.05），年龄、工龄、工种和年有效剂量均对NPB有影响（χ2=7.202~45.571，P<0.05）。结论 NPB能反映出长期小剂量慢性照射对职业受照人群健康的影响。 |
| 英文摘要: |
| Objective To study the effects of sex, age, length of service, type of work and annual effective radiation dose on nucleoplasmic bridge (NPB) in the peripheral blood lymphocytes of radiation workers. Methods The peripheral blood samples of 100 radiation workers in Henan province were collected and the NPB in peripheral blood lymphocytes were measured by CBMN assay. The frequencies of NPB formation and NPB-containing cells were calculated, and the effects of various factors on NPB incidence were analyzed statistically. Results The NPB frequency in radiation workers was higher than that in healthy people (Z=-8.123, P<0.01). Except for sex, the factors of age, length of service, type of work and annual effective dose had significant influences on NPB (χ2=7.202-45.571,P<0.05). Conclusions NPB reflects the effect of low-dose long-term chronic irradiation on the occupational radiation workers. |
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