| 高梦丹,叶旭雪,卢立淮,王琼琼,周清宇,高雅,李益飞,谢聪颖.鞘氨醇-1-磷酸受体-1促进肿瘤转移与放疗抵抗的研究进展[J].中华放射医学与防护杂志,2019,39(8):599-602 |
| 鞘氨醇-1-磷酸受体-1促进肿瘤转移与放疗抵抗的研究进展 |
| Research progress of S1PR1 in tumor metastasis-promoting and radiotherapy resistance |
| 投稿时间：2019-04-02 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.08.007 |
| 中文关键词: 鞘氨醇-1-磷酸受体-1 转移 放疗抵抗 |
| 英文关键词:S1PR1 Metastasis Radiotherapy resistance |
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| 中文摘要: |
| 远处转移是癌症治疗的主要障碍之一。鞘氨醇-1-磷酸受体-1（sphingosine-1-phosphate receptor 1，S1PR1）在恶性肿瘤中过度表达，通过激活下游信号通路增强细胞侵袭和迁移活性、调控上皮间质转化（EMT）以及诱导淋巴管与血管生成，最终导致肿瘤转移的发生。S1PR1与获得性放射抗性的产生也有密切关联。本文就S1PR1及其在肿瘤转移和放疗抵抗中的作用进行综述。 |
| 英文摘要: |
| Distant metastasis is one of the main obstacles to cancer treatment. Overexpression of S1PR1 in malignant tumors enhances cell invasion and migration activity, mediates EMT and induces lymphangiogenesis and angiogenesis via activation of its downstream signaling pathways,eventually results in the occurrence of tumor metastasis. S1PR1 is also closely related to generation of acquired radiotherapy resistance. This article discusses the roles of S1PR1 in tumor metastasis and radiotherapy resistance. |
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