| 黄旭锐,黄海威.放射性脑损伤炎症反应机制的研究进展[J].中华放射医学与防护杂志,2018,38(11):870-873 |
| 放射性脑损伤炎症反应机制的研究进展 |
| Advances in the mechanism of inflammatory response to radiation-induced brain injury |
| 投稿时间：2018-04-15 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.11.014 |
| 中文关键词: 放射性脑损伤 小胶质细胞 活性氧类 炎症介质 白细胞 |
| 英文关键词:Radiation-induced brain injury Microglia Reactive oxygen species Inflammatory mediators Leukocytes |
| 基金项目:广东省科技计划项目（2016A020215040） |
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| 中文摘要: |
| 放射性脑损伤（radiation-induced brain injury， RBI）的发生机制仍不明确，目前多项研究认为炎症反应起重要作用。活性氧类的产生，炎症介质的释放，神经元、胶质细胞、周细胞的相互作用以及外周白细胞的募集等共同促进放射性脑损伤的发生发展。本文就放射性脑损伤炎症反应机制的研究进展进行综述。 |
| 英文摘要: |
| The mechanisms of radiation-induced brain injury (RBI) remain unclear. Currently a number of studies suggest that inflammatory response may play an important role in RBI. The production of reactive oxygen species, the release of inflammatory mediators, the interactions between neurons, glial cells, and pericytes, and the recruitment of peripheral leukocytes all contribute to the development of radiation-induced brain injury. This article reviews the research progress of the inflammatory response mechanism of radiation-induced brain injury. |
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