| 罗辉,乔丽丽,李永翰,等.双硫仑抗肿瘤活性及在放射生物学中的研究进展[J].中华放射医学与防护杂志,2018,38(8):631-634.Luo Hui,Qiao Lili,Li Yonghan,et al.Research progresses of the roles of disulfiram in anticancer activity and radiobiology[J].Chin J Radiol Med Prot,2018,38(8):631-634 |
| 双硫仑抗肿瘤活性及在放射生物学中的研究进展 |
| Research progresses of the roles of disulfiram in anticancer activity and radiobiology |
| 投稿时间：2018-01-12 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.08.014 |
| 中文关键词: 双硫仑 肿瘤 临床研究 分子机制 放射敏感性 |
| 英文关键词:Disulfiram Cancer Clinical studies Molecular mechanism Radiosensitivity |
| 基金项目:国家自然科学基金（81372436） |
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| 中文摘要: |
| 双硫仑（disulfiram，DSF）为临床广泛应用的抗酗酒药物。然而，近年来的一些研究表明，DSF具有极强的抗肿瘤活性，已有临床试验报道其可提高肿瘤患者生存率；并对其抗肿瘤的分子机制进行了深入的阐述。另外，放射生物学研究发现DSF可以减轻射线对机体正常细胞的损伤，并通过其与铜离子形成复合物、抑制肿瘤干细胞、抑制泛素-蛋白酶体活性等机制增强肿瘤细胞的放疗敏感性，极有希望作为放化疗的辅助用药，提高放化疗疗效。本文详细论述了双硫仑抗肿瘤临床研究现状、分子机制，在肿瘤放射生物学中的研究及其应用前景。 |
| 英文摘要: |
| Disulfiram (DSF) has been widely used in clinical treatment of alcoholism. To date, in vivo and in vitro experiments have demonstrated that DSF has strong anti-cancer activity and could improve patient's survival, and the underlying mechanism has been elaborated. In addition, it was reported that, during radiotherapy, DSF could protect normal tissue and cells meanwhile enhance the radiosensitivity of tumor cells by forming complexes with copper ions, suppressing cancer stem cells and inhibiting ubiquitin-proteasome system activity in cancer cells. This review summarizes the completed and ongoing clinical trials of disulfiram, and its anti-tumor mechanisms and advances in radiation biology. |
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