| 高宇,王平,田崇彬,韩林,李杰,王兆男,吴艳延,赵风玲,吕玉民.放射工作人员血清中8-羟基脱氧鸟苷水平研究[J].中华放射医学与防护杂志,2018,38(4):253-257 |
| 放射工作人员血清中8-羟基脱氧鸟苷水平研究 |
| Serum 8-hydroxy-2-deoxyguanosine level of radiation workers in hospitals |
| 投稿时间：2018-01-24 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.04.003 |
| 中文关键词: 电离辐射 放射工作人员 介入放射学 8-羟基脱氧鸟苷 |
| 英文关键词:Ionizing radiation Radiation workers Interventional radiology 8-hydroxy-2-deoxyguanosine |
| 基金项目:河南省重点科技攻关项目（142102310086）；国家重点临床专科建设项目（2011-17） |
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| 中文摘要: |
| 目的 探讨长期低剂量电离辐射对医疗机构的放射工作人员血清中8-羟基脱氧鸟苷（8-OHdG）水平的影响。方法 首先按放射工种分层，随后采用随机数表法选取307名性别、年龄匹配的放射工作人员，删去缺少剂量资料的对象后，共230例纳入本研究，包括放射诊断75例、放射治疗60例、核医学41例和介入放射学54例共4组。采用酶联免疫吸附试验（ELISA）测定其血清中8-OHdG水平。结果 放射诊断、放射治疗、核医学和介入放射学4组放射工作人员之间血清8-OHdG浓度比较，差异有统计学意义（F=9.071，P < 0.05），其中以介入放射工作人员的血清8-OHdG浓度最高（t=-4.773、-3.011、-2.189，P < 0.05）；在不同年有效剂量组和工龄组放射工作人员的血清8-OHdG水平存在差异（F=7.659、3.058，P < 0.05），随着受照剂量和放射工龄的增加，放射工作人员血清8-OHdG水平呈上升趋势（r=0.300、0.142，P < 0.05）。结论 血清中8-OHdG水平可能是暴露于低剂量电离辐射放射工作人员的DNA氧化损伤的潜在生物标志。 |
| 英文摘要: |
| Objective To explore the influence of long-term low-dose ionizing radiation on 8-hydroxy-2-deoxyguanosine(8-OHdG)level in the serum of radiation workers in hospitals. Methods 307 age-and sex-matched hospital radiation workers were recruited by stratified random sampling method. After deleting the subjects without dosage information,230 individuals were divided into four groups according to their job title[including diagnostic radiology(n=75), radiotherapy(n=60), nuclear medicine(n=41)and interventional radiology(n=54)]. Serum 8-OHdG level was measured by ELISA assay. Results According to the statistical analysis, there was significant difference in the serum 8-OHdG level among four groups (F=9.071, P < 0.05), and the content of serum 8-OHdG was significantly higher in the interventional radiology group than that in the groups of diagnostic radiology, radiotherapy and nuclear medicine (t=-4.473, -3.011, -2.189, P < 0.05). There were significant differences in serum 8-OHdG level among different dose groups and working period groups(F=7.659, 3.058, P < 0.05). The serum 8-OHdG levels significantly increased along with exposure dose and working period(r=0.300, 0.142, P<0.05).Conclusions Serum 8-OHdG may be a potential biomarker of oxidative DNA damage in radiation workers exposed to low-dose ionizing radiation. |
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