| 牛雪娜,赵汉玺,朱婉琦,邢力刚.表没食子儿茶酸没食子酸酯用于放射损伤防治的研究进展[J].中华放射医学与防护杂志,2018,38(1):69-72 |
| 表没食子儿茶酸没食子酸酯用于放射损伤防治的研究进展 |
| Research progresses of green tea extract epigallocatechin-3-gallate on preventing and treating radiation injury |
| 投稿时间：2017-07-04 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.01.015 |
| 中文关键词: 放射损伤 表没食子儿茶酸没食子酸酯 防护 |
| 英文关键词:Radiation injury Epigallocatechin-3-gallate Protection |
| 基金项目:山东省自然科学基金（ZR2016HM35） |
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| 中文摘要: |
| 放射治疗是治疗恶性肿瘤的主要手段之一，在治疗过程中易引起正常组织的损伤，如放射性肺损伤、食管损伤、皮肤损伤及造血、免疫功能异常等。绿茶成分表没食子儿茶酸没食子酸酯（EGCG）是茶多酚的主要成分，具有抗炎、抗氧化、抗凋亡及调节免疫力等功能。近年来大量的动物模型实验证实，EGCG具有防治放射损伤的作用，但EGCG防治放射损伤的临床报道不多。本文将从EGCG的抗放射机制及其在放射性损伤中的应用方面，对近年来EGCG在放射损伤防治方面的研究进展进行综述，以期为EGCG的临床应用提供参考。 |
| 英文摘要: |
| Radiotherapy is one of the important cancer therapy methods that can lead to tissue damage including radiation lung injury, radiation esophageal injury,radiation skin damage and abnormal changes in hemopoietic system and immune system. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea. It has been demonstrated that EGCG has biological effects of anti-inflammatory, antioxidant, anti-apoptosis and regulating immunity. Recently some studies of cell and animal models suggest that EGCG has radioprotective effect, but few clinical research was reported. In this review, the studies about EGCG in preventing and treating radiation injury were summarized from anti-radiation mechanism in order to enhance the understanding of the potential clinical application of EGCG. |
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