| 郝亮,汪建,王斌,张西坤,刘玉丽,王俊杰,仲锋,杨焕刚,孙文,牛洪欣.模拟胆管内不同弧度125I粒子链的剂量学研究[J].中华放射医学与防护杂志,2017,37(10):758-762 |
| 模拟胆管内不同弧度125I粒子链的剂量学研究 |
| Dosimetry of 125I seeds in different curvatures of bile ducts |
| 投稿时间：2017-01-26 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.10.007 |
| 中文关键词: 胆管癌 125I粒子链 弧度 剂量学 |
| 英文关键词:Bile duct cancer 125I seed chain Radian Dosimetry |
| 基金项目:山东省科技发展计划项目（2014GSF118182） |
| 作者 | 单位 | E-mail | | 郝亮 | 250062, 济南大学 山东省医学科学院医学与生命科学学院 | | | 汪建 | 250031 济南, 山东省医学科学院附属医院微创外科 | | | 王斌 | 250031 济南, 山东省医学科学院附属医院微创外科 | | | 张西坤 | 250031 济南, 山东省医学科学院附属医院微创外科 | | | 刘玉丽 | 250031 济南, 山东省医学科学院附属医院微创外科 | | | 王俊杰 | 100191, 北京大学第三医院肿瘤放疗科 | | | 仲锋 | 250031 济南, 山东省医学科学院附属医院微创外科 | | | 杨焕刚 | 250031 济南, 山东省医学科学院附属医院微创外科 | | | 孙文 | 250031 济南, 山东省医学科学院附属医院微创外科 | | | 牛洪欣 | 250031 济南, 山东省医学科学院附属医院微创外科 | sdblache@126.com |
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| 中文摘要: |
| 目的 研究不同弧度胆管内125I粒子链剂量学分布情况。方法 在纸上勾画出不同弧度的粒子链模型（弧长=2πr×角度/360），计算弧长为45 mm对应的0°、30°、60°、90°、120°、150°、180°的模型。粒子链模型总长度为45 mm（每枚粒子间距为0 mm）。在粒子链模型向心侧和离心侧的中心点及两端点垂直距离5 mm处画标尺。用激光扫描仪扫描模型。每个弧度模型创建3层图片，模拟直径为8 mm的胆管。将图片导入放射性粒子源植入治疗计划系统（TPS），模拟不同弧度的粒子链。使用TPS勾画大体肿瘤靶区（GTV）用于模拟直径8 mm的胆管，设定粒子初始活度1.85×107 Bq，给予处方剂量60 Gy。计算直径为8 mm模拟胆管的D90和V100，以及粒子链中心点、两端点的向心侧及离心侧5 mm处剂量变化情况。结果 粒子链弧度为30°时，D90（132 Gy）和V100（100%）最高；弧度为60°时，D90（45 Gy）和V100（68%）最低。弧度为30°时，中心点处剂量最高（向心侧剂量为165 Gy，离心侧剂量142 Gy）；弧度为180°时，中心点处剂量最低（向心侧剂量为90 Gy，离心侧剂量50 Gy）。不同弧度时（不含0°），中心点向心侧剂量均高于离心侧；两端点离心侧的剂量均大于向心侧。结论 随着弧度改变，粒子链剂量分布也相应变化，30°时D90、V100最大；弧度近心侧剂量明显高于远心侧。 |
| 英文摘要: |
| Objective To study the dosimetry distribution of 125I seed chains with different radians in different curvatures of bile ducts.Methods The outlines were drawn on the papers, which are the seed chain models with different radians. Radians formula (radian length=2πr×angle/360) was used to calculate the corresponding 0°, 30°, 60°, 90°, 120°, 150ånd 180° models with a radian length at 45 mm, for the total length of seed chain model was 45 mm, and the seeds, had no interval or linear arrangements. The image was transmitted to the Brachytherapy planning system for seeds implantation(TPS) to simulate the seed chains with different radians. Using TPS to delineate the tumor target area, of which the activity was set as 1.85×107 Bq, and the prescription dose was 60 Gy. It was prescribed to simulate the bile duct (diameter at 8 mm). TPS were used to calculate the D90 and V100 of the simulated bile duct with the diameter at 8 mm, and explore dosimetry of the points at the centripetal and centrifugal sides with 5 mm vertical distance which from two endpoints and center of seed chains with different radians.Results When the radian of seed chain was 30°, the D90 and the V100 were the highest (the D90 was 132 Gy; the V100 was 100%). While the radian was 60°, the D90 and the V100 were the lowest (the D90 was 45 Gy, the V100 was 68%). As the radian was 30°, the highest dose was in the center (dose in the centripetal side was 165 Gy, and centrifugal side dose was 142 Gy). The center has the lowest dose as the radian up to 180°(dose in the centripetal side was 90 Gy, and centrifugal side dose was 50 Gy). Among all radians, dose in the centripetal side was always higher than centrifugal side in the center. Between two endpoints, dose in the centrifugal side was higher than centripetal.Conclusions Distribution of seed chain dosage also changed along with the change of radian. When the radian of seed chain was 30°, the D90 and the V100 were the highest. The centripetal dose was higher than that of the centrifugal side. |
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