| 廉艳东,曾亿勇,陈兆乾,等.低浓度等渗对比剂结合低管电压在兔肝脏CT灌注成像中的可行性研究[J].中华放射医学与防护杂志,2017,37(8):630-634.Lian Yandong,Zeng Yiyong,Chen Zhaoqian,et al.Feasibility study of low concentration iso_osmolar contrast agent and low tube voltage for rabbit hepatic computed tomography perfusion scanning[J].Chin J Radiol Med Prot,2017,37(8):630-634 |
| 低浓度等渗对比剂结合低管电压在兔肝脏CT灌注成像中的可行性研究 |
| Feasibility study of low concentration iso_osmolar contrast agent and low tube voltage for rabbit hepatic computed tomography perfusion scanning |
| 投稿时间：2017-01-07 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.08.015 |
| 中文关键词: 肝脏 体层摄影术,X线计算机 灌注成像 辐射剂量 对比剂 |
| 英文关键词:Liver Tomography,X-ray computer Perfusion computed tomography Radiation dose Contrast |
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| 中文摘要: |
| 目的 探讨低管电压和低浓度等渗对比剂结合迭代算法在家兔肝脏CT灌注成像应用的可行性。方法 健康新西兰大白兔15只，每只兔子分别进行两次肝脏CT灌注检查，两次检查间隔时间为24 h。第1次扫描作为常规组，使用100 kV和370 mg I/ml对比剂，传统滤过反投影法（FBP）重建图像；第2次扫描作为双低组，采用低管电压80 kV和270 mg I/ml对比剂，并采用第3代适应性迭代降噪（AIDR-3D）重建图像。两名医师对获得的肝脏灌注图进行双盲法评分，并比较观察者评分的一致性。对两组的灌注参数值包括肝动脉灌注量（HAP）、门静脉灌注量（PVP）、肝灌注指数（HPI）及全肝灌注量（TLP）值和腹主动脉平均CT值、图像噪声（N）、信噪比（SNR）、对比信噪比（CNR）、图像优良指数（FOM）进行配对样本t检验。计算和比较不同条件下的有效剂量E和碘的摄入量。结果 两组肝灌注图像的主观评分分别为（4.0±0.76）、（4.3±0.62）分，差异无统计学意义（P>0.05）。两名医师评分的一致性良好（Kappa=0.81，P<0.05）。两组中的PVP、HAP、HPI及TLP值差异无统计学意义（P>0.05）。双低组剂量E为19.85 mSv，较常规组的32.43 mSv降低38.79%。双低组总碘量较常规组减低27.03%。结论 使用等渗低浓度对比剂结合低管电压肝脏灌注检查可以在不降低图像质量的前提下明显减低辐射剂量和碘摄入量。 |
| 英文摘要: |
| Objective To investigate the feasibility of low-concentration iso_osmolar contrast agent together with low tube voltage and iterative reconstruction algorithm in rabbit liver computed tomography (CT) perfusion imaging. Methods A total of 15 healthy New Zealand rabbits were scanned twice of liver CT perfusion scans each with 24 hours interval. The first scan (routine group) was acquired at 100 kV and 100 mAs with ultravist (370 mg/ml), while the second ("double low" group) was acquired at 80 kV and 100 mAs with iodixanol (270 mg/ml) at 24 hours after the first scan. The obtained images were reconstructed with filtered back projection (FBP) and adaptive iterative dose reduction(AIDR-3D) algorithms in the controlled and experimental groups, respectively. The perfusion parameters including hepatic artery perfusion(HAP), portal vein perfusion(PVP), hepatic perfusion index(HPI), and total liver perfusion(TLP) and image quality as image quality score, average CT value of abdomen aorta, signal-to-noise ratio(SNR), carrier-to-noise ratio(CNR),and figure of merit(FOM)were compared used pair t-test or Mann-Whitney U-test between the two groups wherever appropriate. The effective radiation dose and iodine intake were also recorded and compared. Results The image quality and perfusion parameters had no significantly different between the two groups except for FOM. The effective radiation dose and iodine intake were 38.79% and 27.03% lower in the "double low" group. Conclusions Low concentration iso_osmolar contrast agent (iodixanol, 270 mg/ml) together with low tube voltage (80 kV) helps to reduce radiation dose and iodine intake without compromising perfusion parameters and image quality in liver CT perfusion imaging. |
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