中华放射医学与防护杂志

苏垠平,谭光享,雷淑洁,等.阳江高本底女性居民低剂量辐射照射与颈动脉中内膜厚度关系的初步研究[J].中华放射医学与防护杂志,2016,36(9):682-687.Su Yinping,Tan Guangxiang,Lei Shujie,et al.Preliminary research on relationship between long-term low dose radiation exposure and the carotid intima-media thickness of female residents in high background radiation area in Yangjiang, China[J].Chin J Radiol Med Prot,2016,36(9):682-687

阳江高本底女性居民低剂量辐射照射与颈动脉中内膜厚度关系的初步研究

Preliminary research on relationship between long-term low dose radiation exposure and the carotid intima-media thickness of female residents in high background radiation area in Yangjiang, China

投稿时间：2016-02-16

DOI：10.3760/cma.j.issn.0254-5098.2016.09.009

中文关键词: 颈动脉中内膜厚度长期低剂量辐射高本底地区动脉粥样硬化

英文关键词:Carotid intima-media thickness Long-term low dose radiation exposure High background radiation area Atherosclerosis

基金项目:中日合作阳江地区放射流行病研究（901004）

作者	单位	E-mail
苏垠平	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室
谭光享	510300 广州, 广东省职业病防治院
雷淑洁	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室
邹剑明	510300 广州, 广东省职业病防治院
张素芬	510300 广州, 广东省职业病防治院
刘建香	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室
李小亮	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室
孙全富	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室	qfusun@nirp.cn
秋葉澄伯	890-8520 鹿儿岛, 日本鹿儿岛大学医学与口腔学研究所

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中文摘要:

目的探索长期低剂量电离辐射对人群心脑血管疾病的影响。方法选择阳江高本底地区γ外照射剂量率最高的4个管区，对照地区选择了距中心镇距离与高本底地区所选管区距中心镇距离相近的2个管区，高本底地区和对照地区分别选取50岁以上女性居民各100名，通过超声检查测量颈动脉中内膜厚度；采集外周静脉血样本，测定血液生化指标，包括总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白；测量血压、身高及体重，通过问卷调查收集个人生活史和居住史。同时，依据既往研究所测量的室内外环境地表γ剂量率及调查的年龄别居留因子，估算个人终生累积剂量。结果阳江高本底与对照地区居民的平均累积剂量分别为（161.2±38.6）和（43.7±7.3）mSv，平均年龄分别为（65.2±10.4）和（60.7±8.0）岁。高本底地区居民颈动脉中内膜厚度左、右两侧分别为（1.0±0.3）和（1.0±0.2）mm，对照地区左右两侧颈动脉中内膜厚度均为（0.9±0.2）mm。多元回归分析显示，调整年龄、血压、体质量指数（BMI）、血脂因素后，个人终生累积剂量为左颈动脉中内膜增厚的一个危险因素（β_左=0.000 7，P<0.05）。不同剂量组（<50，50~，100~，200~ mSv）经调整后左动脉中内膜厚度平均值分别为0.9、1.0、0.9、1.1 mm。结论长期低剂量辐射可能有加速血管老化、增加动脉粥样硬化的风险。

英文摘要:

Objective To explore the effect on cardiovascular and cerebrovascular diseases for people due to long-term low dose radiation exposure. Methods Four regions were selected from the high background radiation area (HBRA) in Yangjiang, featuring highest external γ radiation dose rate, and two regions from control area (CA) was chosen at the similar distance from downtown as four regions selected from the high background radiation area. Each of one hundred female residents aged more than 50 years old respectively selected from the HBRA in Yangjiang and in the CA. The carotid intima-media thickness (CIMT) was measured using ultrasonic examination. The peripheral venous was sampled to measure the levels of total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol. Blood pressure, height and weight were also measured. Personal life and living history were collected through questionnaires. The estimation of personal lifetime accumulated radiation dose was based on γ-ray dose rate from indoor and outdoor and the age-related occupancy factor obtained from the previous studies. Results There were statistically significant differences of accumulated radiation dose and CIMT of residents between Yangjiang HBRA and CA[(161.2±38.6) mSv vs. (43.7±7.3) mSv, L (1.0±0.3) mm/R (1.0±0.2) mm vs. L&R (0.9±0.2) mm]. The average age was (65.2±10.4) years old for HBRA and (60.7±8.0) years old for CA,respectively. After adjusting confounding factors, including age, blood pressure, BMI and serum cholesterol, the increased cumulative radiation dose was shown to be a risk factor for thickening left CIMT (β=0.000 7,P<0.05). The left CIMT for different dose groups was 0.9, 1.0, 0.9 and 1.1 mm for <50, 50-100, 100-200, >200 mSv, respectively. Conclusions Long-term low dose radiation exposure may age the vascular, and increasing the risk of atherosclerosis.

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