| 李思妹,王雅棣,陈建平,张富利,陈点点,路娜.宫颈癌螺旋断层调强放疗的外放边界研究[J].中华放射医学与防护杂志,2016,36(3):216-219 |
| 宫颈癌螺旋断层调强放疗的外放边界研究 |
| Margins of planning target volume in cervix cancer with tomotherapy |
| 投稿时间：2015-10-29 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.03.011 |
| 中文关键词: 宫颈癌 螺旋断层放疗 图像引导放疗 摆位误差 外扩边界 |
| 英文关键词:Cervical cancer Tomotherapy Image guided radiation therapy (IGRT) Setup errors Margin of planning target volume |
| 基金项目:首都卫生发展科研专项(2011-5021-05) |
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| 中文摘要: |
| 目的 通过自动和自动+手动配准分别得出的宫颈癌放疗位置误差,评估自动+手动配准的必要性,并给出螺旋断层放疗计划靶区(PTV)外扩边界值(MPTV)。方法 回顾性分析2012年6月至2014年12月入组单纯放疗宫颈癌患者29例,采集每周至少两次治疗前兆伏级CT(MVCT)与计划CT图像进行自动配准,得出自动配准位置误差值(AR),并对AR值再行手动配准,得出自动+手动配准位置误差总移动值(TS),比较AR和TS值的差异,并计算MPTV。结果 共获取443幅MVCT图像,在x、y、z轴和角度旋转方向上AR值分别为(-0.9±2.3)、(0.0±3.1)、(1.0±2.6)mm和0.2°±0.8°,TS值分别为(-0.8±1.8)、(-0.4±3.4)、(1.4±2.5)mm和0.1°±0.5°。除x轴以外,AR和TS两组结果差异有统计学意义(t=5.1、-5.2、3.2,P<0.05);x、y和z轴各方向MPTV相应为4.6、5.7和3.3 mm。结论 宫颈癌螺旋断层放疗中,自动配准基础上的手动配准是必要的。建议行螺旋断层宫颈癌单纯放疗患者外扩PTV左右、头脚、前后方向分别为5、6、4 mm。 |
| 英文摘要: |
| Objective To determine the margins of planning target volume (MPTV) in primary cervical cancer patients with tomotherapy and evaluate the importance of automatic registration(AR) plus manual registration. Methods The setup errors of 29 primary cervical cancer patients receiving external radiation from June 2012 to Dec 2014 were measured by megavoltage computed tomography (MVCT), which were performed at least two times weekly before treatment and were registered with the planning CT. The setup errors between automatic registration and total shift(TS) including both AR and manual registration were compared MPTV was calculated. Results Setup errors were collecte from 443 sets of MVCT in 29 patients. AR and total shift (TS) values in the x, y, z directions and rotation angle were (-0.9±2.3), (0.0±3.1), (1.0±2.6) mm, 0.2°±0.8° and (-0.8±1.8), (-0.4±3.4), (1.4±2.5) mm, 0.1°±0.5°, respectively. There were statistically significant differences between the two groups in all directions except for the x axis (t=5.1, -5.2, 3.2, P<0.05). MPTV were 4.6, 5.7, 3.3 mm in the x, y, z directions, respectively. Conclusions Manual registration is necessary after automatic registration in cervical cancer patients with tomotherapy. For patients with cervical cancer treated by tomotherapy, planning target volume MPTV parameters are suggested to be 5, 6, 4 mm in the x, y, z directions. |
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