| 岳丹,杨永净,赵玲,吴洪芬,卜明伟,赵继红,曹玲,马瑞,杨金磊,刘士新.CBCT图像引导鼻咽癌调强放疗的精确性研究[J].中华放射医学与防护杂志,2016,36(3):211-215 |
| CBCT图像引导鼻咽癌调强放疗的精确性研究 |
| Clinical feasibility and accuracy of image guidance with kilovoltage cone-beam computed tomography in nasopharyngeal carcinoma intensity-modulated radiotherapy |
| 投稿时间：2015-09-29 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.03.010 |
| 中文关键词: 图像引导放疗 千伏级锥形束CT 调强放疗 鼻咽癌 摆位误差 |
| 英文关键词:Image guided radiation therapy (IGRT) Cone-beam computerized tomography (CBCT) Intensity-modulated radiotherapy (IMRT) Nasopharyngeal carcinoma (NPC) Setup errors |
| 基金项目:吉林省科技发展计划项目(20090450) |
| 作者 | 单位 | E-mail | | 岳丹 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 杨永净 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 赵玲 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 吴洪芬 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 卜明伟 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 赵继红 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 曹玲 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 马瑞 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 杨金磊 | 130012 长春, 吉林省肿瘤医院放疗一科 | | | 刘士新 | 130012 长春, 吉林省肿瘤医院放疗一科 | liushixin1964@sina.com |
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| 中文摘要: |
| 目的 探讨千伏级锥形束CT(kV-CBCT)图像引导技术对鼻咽癌调强放疗精确性的影响。方法 331例鼻咽癌调强放疗患者每周行kV-CBCT校正扫描。计算系统误差(Σ)和随机误差(σ),摆位扩边按照Van Herk公式计算(2.5Σ+0.7σ)。结果 分析3 972个CBCT扫描图像。校正前在x、y、z方向上的平移误差和旋转误差分别为(0.95±0.79)、(1.04±0.66)、(1.14±0.63) mm 和1.32°±0.99°、1.45°±1.37°、1.25°±1.35°,校正后分别为(0.56±0.44)、(0.56±0.51)、(0.42±0.63) mm 和0.78°±0.76°、0.62°±0.85°、0.75°±0.64°。在x、y、z方向校正前的计划靶区扩边值(MPTV)分别为2.93、3.06和3.30 mm,校正后为1.71、1.76和1.49 mm。结论 应用kV-CBCT校正鼻咽癌调强放疗摆位中的线性和旋转误差明显缩小系统和随机误差,使得MPTV缩小到2 mm以内,提高了放疗的精确性。 |
| 英文摘要: |
| Objective To evaluate the set-up accuracy of intensity-modulated radiotherapy (IMRT) with the use of kilovoltage X-ray cone-beam computed tomography (kV-CBCT) and establish the proper planning target volume margins (MPTV) in nasopharyngeal carcinoma (NPC) patients.MethodsA total of 331 NPC patients were scheduled to undergo IMRT were retrospectively reenrolled in the study. An on-line correction protocol was adopted weekly since the implementation of kV-CBCT. The systematic (Σ) and random (σ) setup errors were calculated at different correction threshold levels. The MPTV were calculated according to the van Herk formula (2.5Σ+0.7σ). Results A total of 3 972 CBCT scans were analyzed. The pre-correction translational setup error and rotation setup error in x, y and z directions were (0.95±0.79), (1.04±0.66), (1.14±0.63) mm and 1.32°±0.99°, 1.45°±1.37°, 1.25°±1.35°. The post-correction were (0.56±0.44), (0.56±0.51), (0.42±0.63)mm and 0.78°±0.76°, 0.62°±0.85°, 0.75°±0.64°, respectively. Pre-correction MPTV were 2.93, 3.06 and 3.30 mm along the x, y and z axes; post-correction were 1.71, 1.76 and 1.49 mm. Conclusions kV-CBCT based online correction increased the accuracy of IMRT and reduced MPTV(<2.0 mm), by decreasing both the systematic and random errorsfor NPC. |
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