| 高露,姜晶,谭淼,宰宇,让蔚清,周平坤.天然高本底辐射对人群外周血淋巴细胞染色体畸变率影响的Meta分析[J].中华放射医学与防护杂志,2014,34(12):889-894 |
| 天然高本底辐射对人群外周血淋巴细胞染色体畸变率影响的Meta分析 |
| Effects of high natural background radiation on chromosome aberration frequency of peripheral blood lymphocytes of long-term exposed inhabitants: a Meta analysis |
| 投稿时间：2014-04-21 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.12.003 |
| 中文关键词: 高本底辐射 染色体畸变 Meta分析 |
| 英文关键词:High natural background radiation Chromosome aberration Meta-analysis |
| 基金项目:国家863项目(2012AA063501);湖南省研究生科研创新项目(CX2014B401) |
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| 中文摘要: |
| 目的 用Meta分析方法综合评估长期天然高本底辐照对人群外周血染色体畸变率的影响. 方法 检索国内外相关中英文数据库文献,并按照事先定义的纳入和排除标准,剔除不符合要求的文献,对纳入文献采用Meta分析方法进行综合定量分析,对9篇有染色体畸变率的研究进行综合分析,其中,2篇为单独报道易位率,2篇为单独报道非稳定性畸变率,综合报道的5篇.高本底辐射组研究总人数17 777人,对照组总人数10 386人.用Stata 12.0进行分析,Q检验和I2检验反映异质性的大小,发表偏倚用漏斗图法、Begg秩相关和Egger线性回归法识别. 结果 长期居住于天然高本底辐射地区的居民外周血染色体易位率和非稳定性畸变(双着丝粒+环状染色体、断片)率高于对照地区,其OR和95%CI分别为:1.57(1.10,2.24)和2.04(1.32,3.14);对易位率影响的研究中,男性、女性、成人和中国地区的OR和95%CI分别为1.24(1.09,1.42)、1.37(1.17,1.60)、1.17(1.05,1.30)、1.38(1.25,1.51),异质性检验I2分别为0.00、0.00、69.50%和0.00;对非稳定性畸变率影响的研究中,女性、成人、儿童、伊朗和中国地区的OR和95%CI分别为3.78(2.40,5.97)、2.60(2.25,3.00)、1.03(0.85,1.24)、3.19(2.46,4.13)和1.64(1.33,2.02),异质性检验I2分别为:0.00、69.60%、0.00、21.60%和0.00;高本底辐射、性别和年龄是上述异质性的来源. 结论 长期暴露于天然高本底辐射会增加外周血淋巴细胞染色体易位率和非稳定性畸变率,应综合分析其对高本底辐射暴露人群产生的健康风险,为建立防护措施和出台相关政策提供科学依据. |
| 英文摘要: |
| Objective To quantitatively analyze the effects of high background radiation area (HBRA) on the frequencies of translocation and unstable chromosome aberrations in human peripheral blood lymphocytes.Methods Based on the data from 9 published articles retrieved from 7 electronic databases, the Meta-analysis was performed to evaluate the effects of high natural background radiation(HNBR) on the frequencies of chromosome aberrations in the peripheral blood lymphocytes in 17 777 persons from HBRA and 10 386 from the control area (CA). Cochrane's Q and I2 statistics were used to evaluate heterogeneity among studies and pooling odds ratio (OR) with 95% confidence intervals (95%CI) were calculated using random-effect models. Publication bias was also calculated by funnel plot, Egger linear regression test and Begg rank correlation test. Results The pooling OR of translocation [OR(95%CI)=1.57(1.10-2.24)] and unstable chromosome aberration [OR(95%CI)=2.04(1.32-3.14)] of long-term exposed inhabitants living in HBRA were higher than control. The subgroup analysis showed that, for translocation, the OR (95% CI) were 1.24 (1.09-1.42, I2=0.00) for male, 1.37 (1.17-1.60, I2=0.00) for female, 1.17 (1.05-1.30, I2=69.50%) for adults, and 1.38 (1.25-1.51, I2=0.00) for Chinese. For unstable chromosome aberration, the OR(95% CI) were 3.78 (2.40-5.97, I2=0.00) for female, 2.60 (2.25-3.00, I2=69.60%) for adults, 1.03(0.85-1.24, I2=0.00) for children, 3.19 (2.46-4.13, I2=21.60%) for Iranian, and 1.64 (1.33-2.02, I2=0.00) for Chinese. HBRA, age and sex differences were the reasons of above heterogeneity. Conclusions To the inhabitants living in HBRA, the frequencies of translocation and unstable chromosome aberration of peripheral blood lymphocytes are higher than those in control area. More comprehensive analysis should be performed to assess the health risk in HBRA inhabitants, which may arise new stragety in radiation protection. |
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