| 段益利,李建彬,张英杰,等.4D-CT与PET-CT勾画非小细胞肺癌原发肿瘤IGTV的比较研究[J].中华放射医学与防护杂志,2014,34(10):753-757.Duan Yili,Li Jianbin,Zhang Yingjie,et al.Comparison of 4D-CT and PET-CT based internal gross tumor volumes delineation for non-small-cell lung cancer[J].Chin J Radiol Med Prot,2014,34(10):753-757 |
| 4D-CT与PET-CT勾画非小细胞肺癌原发肿瘤IGTV的比较研究 |
| Comparison of 4D-CT and PET-CT based internal gross tumor volumes delineation for non-small-cell lung cancer |
| 投稿时间：2013-12-22 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.10.008 |
| 中文关键词: 非小细胞肺癌 FDG PET-CT 4D-CT 内大体肿瘤体积 标准摄取值 |
| 英文关键词:Non-small cell lung cancer Fluorodeoxyglucose positron emission tomography computed tomography Four-dimensional computed tomography Internal gross target volume Standardized uptake value |
| 基金项目:国家自然科学基金青年基金（81201735）；山东省科技发展计划项目（2012GSF11839）；山东省自然科学基金（ZR2011HM004） |
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| 中文摘要: |
| 目的：比较基于4D-CT 10个呼吸时相所构建非小细胞肺癌（NSCLC）内大体肿瘤体积（IGTV10）与基于18F-FDG PET-CT不同SUV值勾画所得靶区（IGTVPET）间体积及位置差异。方法：10例NSCLC患者序贯完成胸部3D-CT、4D-CT增强扫描，并基于相同体位固定方式及定位参数行18F-FDG PET-CT扫描。在4D-CT 10个呼吸时相图像上勾画原发肿瘤大体肿瘤体积（GTV）并融合获得IGTV10。基于PET图像不同SUV值（≥1.5、≥2.0、≥2.5、≥3.0）、最大SUV值的不同百分比（≥20%、≥25%、≥30%、≥35%、≥40%）及目测法勾画原发肿瘤靶区（IGTVPET），比较IGTVPET与IGTV10靶区间位置、体积大小、包含度（DI）和适形指数（CI）差异。结果：除IGTVPET1.5外，其余IGTVPET与IGTV10中心点坐标在上下方向差异均有统计学意义（Z=-2.703~-2.293，P<0.05）。IGTVPET2.0与IGTV10体积大小最接近，其次是IGTVPET20%，二者同IGTV10体积比间差异无统计学意义（Z=-0.415，P>0.05）。IGTV10对IGTVPET1.5的DI高于IGTV10对其余IGTVPET的DI（Z=-2.803~-2.429，P<0.05）。IGTVPET2.0与IGTV10的CI最高，高于IGTVPET35%、IGTVPET40%、IGTVPET2.5、IGTVPET3.0与IGTV10的CI（Z=-2.803~-2.191，P<0.05）。结论：基于PET SUV值≥2.0及SUVmax的百分比≥20%勾画所得的IGTVPET2.0、IGTVPET20%与基于4D-CT 10个时相GTV构建的IGTV10体积大小较为相近，但IGTVPET2.0、IGTVPET20%与IGTV10间空间错位较明显，二者均不能代替IGTV10。 |
| 英文摘要: |
| Objective: To compare the positional and volumetric differences of internal gross target volumes (IGTVs) delineation based on four-dimensional CT (4D-CT) images and different standardized uptake values of 18F-fluorodeoxyglucose positron emission tomography CT (PET-CT) for the primary non-small cell lung cancer (NSCLC). Methods: Ten NSCLC patients underwent enhanced three-dimensional CT scan followed by enhanced 4D-CT scan of the thorax under normal free breathing and then 18F-FDG PET-CT scan was performed based on the same position and positioning parameters. The gross target volumes (GTVs) of 10 phases of 4D-CT were contoured and IGTV10 was obtained by fusion of the 10 GTVs. IGTVPET were determined with nine different threshold methods using the auto-contouring function and manual contouring. The differences of position, volume, degree of inclusion (DI) and conformity index (CI) between IGTVPET and IGTV10 were compared. Results: For superior-inferior (SI) directions, there were statistically significant differences between the centric coordinate parameters of IGTVPET (excluding IGTVPET1.5) and IGTV10 (Z=-2.703--2.293, P<0.05). In volume terms, IGTVPET2.0 was approximated close to IGTV10 with median volume ratios of 0.90, followed by IGTVPET20% to IGTV10 with median volume ratios of 0.84, but there was no significant difference between them. The DI of IGTVPET1.5 in IGTV10 was higher than the DIs of other IGTVPET in IGTV10 (Z=-2.803--2.429, P<0.05). The CI of IGTVPET2.0 and IGTV10 was superior than the CIs of IGTVPET35% and IGTV10, IGTVPET40% and IGTV10, IGTVPET2.5 and IGTV10, IGTVPET3.0 and IGTV10 (Z=-2.803--2.191, P<0.05). Conclusions: The IGTVPET contoured by SUV≥2.0 or 20% of the maximal SUV are approximate close to IGTV10 in target size, but the extent of spatial mismatch is relatively obvious between them. So neither IGTVPET20% nor IGTVPET2.0 could replace IGTV10 . |
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