| 倪千喜,唐迪红,张九堂.妇科肿瘤后装逆向调强放疗的初步临床研究[J].中华放射医学与防护杂志,2014,34(4):286-288.Ni Qianxi,Tang Dihong,Zhang Jiutang.Preliminary clinical research on the afterloading brachytherapy inverse intensity-modulated radiotherapy of gynecological tumor[J].Chin J Radiol Med Prot,2014,34(4):286-288 |
| 妇科肿瘤后装逆向调强放疗的初步临床研究 |
| Preliminary clinical research on the afterloading brachytherapy inverse intensity-modulated radiotherapy of gynecological tumor |
| 投稿时间：2013-06-19 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.04.012 |
| 中文关键词: 妇科肿瘤 逆向模拟退火优化技术 剂量学 危及器官 放疗并发症 |
| 英文关键词:Gynecologic tumor Inverse planning simulated annealing(IPSA) Dosimetry Organs at risk Radioactive complications |
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| 中文摘要: |
| 目的 评价后装逆向调强放疗技术在妇科肿瘤治疗中的临床价值。方法 选取20例Ⅰ~Ⅲ期宫颈癌患者，采用随机数字表和余数分组的方法分为A、B两组，各10例。A组病例行后装逆向调强放疗，B组病例行三维适形后装放疗。分析两组患者的靶区剂量分布、危及器官受量、放疗并发症及近期疗效。 结果 A组靶区剂量均匀度指数（HI）为52.43±0.45，好于B组的46.37±1.45（t=0.92，P<0.05）；A组直肠、膀胱最大受量Dmax分别比B组低37%、35%（t=1.34、1.39，P<0.05），A组75%处方剂量的直肠、膀胱受照体积V75约为B组的1/2（t=1.23、1.13，P<0.05）；A组局部控制率96%好于B组的 93%（t=1.25，P<0.05）。结论 后装逆向调强放疗优于三维适形后装放疗，值得在妇科肿瘤治疗中广泛应用。 |
| 英文摘要: |
| Objective To evaluate the clinical value of the afterloading brachytherapy inverse intensity-modulated radiotherapy of gynecological tumor. Methods Twenty patients with cervical cancer, were randomly divided into A and B groups, 10 cases for each group. Group A received the afterloading brachytherapy inverse intensity-modulated radiotherapy. Group B received the three-dimensional comformal afterloading brachytherapy. The target volume dose distribution, organs at risk (rectum, bladder), short-term curative effect and radioactive complications were analyzed on both groups. Results The dose homogeneity index of the target volume of group A was 52.43±0.45, better than that of group B(46.37±1.45)(t=0.92,P<0.05).The maximum dose of rectum and bladder of group A were about 37%, 35%, less than that of group B(t=1.34,1.39,P<0.05). The 75% prescription dose irradiated volume of rectum and bladder of group A were about only 1/2 of group B(t=1.23,1.13,P<0.05).The local control rate of 96% for group A was better than 93% for group B(t=1.25,P<0.05). Conclusions Afterloading brachytherapy inverse intensity-modulated radiotherapy technique could be better than the three-dimensional comformal afterloading brachytherapy. It should be recommended for gynecological tumor. |
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