| 宦佳乐,邢鹏飞,徐莹莹,等.颈淋巴结阴性鼻咽癌放疗范围的选择：一个基于荟萃分析的结果[J].中华放射医学与防护杂志,2014,34(4):275-278.Huan Jiale,Xing Pengfei,Xu Yingying,et al.The selection of irradiation volume for neck lymph node-negative nasopharyngeal carcinoma：the results based on a Meta-analysis study[J].Chin J Radiol Med Prot,2014,34(4):275-278 |
| 颈淋巴结阴性鼻咽癌放疗范围的选择：一个基于荟萃分析的结果 |
| The selection of irradiation volume for neck lymph node-negative nasopharyngeal carcinoma：the results based on a Meta-analysis study |
| 投稿时间：2013-09-02 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.04.009 |
| 中文关键词: 鼻咽癌 颈部淋巴结转移 放疗范围 荟萃分析 |
| 英文关键词:Nasopharyngeal neoplasm Neck lymph node metastasis Radiation target volume Meta-analysis |
| 基金项目:江苏省“科教兴卫”医药重点人才项目（RC 2011144）；江苏高校优势学科建设工程项目（PAPD） |
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| 中文摘要: |
| 目的 通过荟萃分析探讨颈淋巴结阴性鼻咽癌病例颈部放疗的适宜范围。方法 从Pubmed、Embase、Cochrane和万方数据库检索出1990年1月至2013年6月期间公开发表的相关文献，筛选出符合入组标准的文献，采用固定效应模型对接受上颈和全颈放疗病例的数据进行比值比（OR）的综合分析，分析指标包括5年颈部局部控制率、颈部照射野内局部控制率和颈部照射野外局部控制率。结果 共有5篇文献符合入组标准，均属回顾性研究。5项研究共有1 333例患者入组，其中970例接受上颈放疗，363例接受全颈放疗。上颈和全颈放疗的病例之间的5年全颈局部控制率、颈部照射野内局部控制率和颈部照射野外局部控制率差异无统计学意义，OR值分别为0.89（95%CI：0.41~1.94）；1.29（95%CI：0.58~2.88）和0.42（95%CI：0.07~2.36）。结论 颈部淋巴结阴性鼻咽癌颈部放疗范围选择上颈部照射是合适的。 |
| 英文摘要: |
| Objective To study the appropriate neck irradiation volume for neck lymph node-negative nasopharyngeal carcinoma patients by Meta-analysis. Methods The related references published from Jan 1990 to Jun 2013 were searched in Pubmed, Embase, Cochrane and Wangfang Databases. The qualified references for enrollment criteria were screened and the relative data were collected. The OR (Odds ratio) value by fixed effect model was used to evaluate the data for patients who received radiotherapy between the upper neck and whole neck irradiation. The endpoints including 5-year neck local control rate (LCR), neck-in-irradiation LCR, and neck-outsides-irradiation LCR. Results Five qualified references were screened and belonged to respective research. There enrolled 1 333 patients, including 970 patients who received the upper neck irradiation and 363 patients who received the whole neck irradiation, respectively. The forest plots revealed that there were no significant differences for 5-year neck LCR, neck-in-irradiation LCR, and neck-outsides-irradiation LCR for patients received radiotherapy between the upper neck and whole neck irradiation. These OR values were 0.89 (95%CI: 0.41-1.94), 1.29 (95%CI: 0.58-2.88) and 0.42 (95%CI: 0.07-2.36), respectively. Conclusions The Meta-analysis results suggest that irradiation to the upper neck for neck lymph node-negative nasopharyngeal carcinoma can be appropriate. |
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