| 赵蕾,郭金栋,吕长兴.小细胞肺癌患者预防性全脑放射治疗疗效及健康相关生命质量分析[J].中华放射医学与防护杂志,2013,33(3):294-298.ZHAO Lei,GUO Jin-dong,LÜ Chang-xing.Efficacy and Health-Related Quality of Life for small cell lung cancer patients after prophylactic cranial irradiation[J].Chin J Radiol Med Prot,2013,33(3):294-298 |
| 小细胞肺癌患者预防性全脑放射治疗疗效及健康相关生命质量分析 |
| Efficacy and Health-Related Quality of Life for small cell lung cancer patients after prophylactic cranial irradiation |
| 投稿时间：2012-10-01 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.03.019 |
| 中文关键词: 小细胞肺癌 预防性全脑放射治疗 脑转移 健康相关生命质量 疗效 |
| 英文关键词:Small cell lung cancer Prophylactic cranial irradiation Brain metastasis Health related quality of life Therapeutic efficacy |
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| 中文摘要: |
| 目的 分析小细胞肺癌患者行预防性全脑放射治疗(PCI)的生存率、脑转移发生率及健康相关生命质量。方法 分析2007年8月至2011年4月42例接受预防性全脑放射治疗的小细胞肺癌患者的临床资料,以Kaplan-Meier法计算生存率, 采用非参数Wilcoxon test法比较PCI治疗前后患者的健康相关生命质量(HRQOL)评分。结果 42例患者PCI后的中位生存期为23个月(95%CI,15.05~30.95),中位无进展生存期为17个月(95%CI,14.33~19.67),PCI后的1年、2年和3年生存率分别为85.5%、45.8%和36.6%。全组患者行PCI后至发生脑转移的中位时间为15个月(95%CI,12.44~17.56),1年和2年的无脑转移发生率分别为77.6%和54.1%。健康相关生命质量分析,除认知功能(PCI后6周及6个月Z=-4.69、-3.36,P<0.05)外,PCI对其他功能影响较小,但出现一定症状的不良反应。结论 局限期小细胞肺癌放化疗后达到完全或接近完全缓解以及广泛期小细胞肺癌化疗有效的患者中进行PCI,可显著降低脑转移发生率,延长生存时间,且不良反应低,短期内对患者的总体生活质量未有明显影响。 |
| 英文摘要: |
| Objective To analyze the survival, brain metastases and health-related quality of life(HRQOL) for small cell lung cancer patients after prophylactic cranial irradiation(PCI).Methods From Aug 2007 to Apr 2011, 42 small cell lung cancer patients were eligible for analysis. Overall survival rate was estimated by the Kaplan-Meier method. The HRQOL scores before and after PCI were compared by the nonparameter wilcoxon test.Results The median survival time from the start of PCI was 23 months(95%CI,15.05-30.95),progression free survival time was 17 months (95%CI,14.33-19.67),1-,2- and 3-year survival rates were 85.5%,45.8% and 36.6%, respectively. The median time from PCI to brain metastases was 15 months(95%CI,12.44-17.56),1- and 2-year brain metastases rates were 77.6% and 54.1%. PCI had a little influence on HRQOL scales except for cognitive function.Conclusions For patients with limited stage small cell lung cancer who achieve complete or nearly complete remission after initial treatment as well as patients with extensive stage who respond to initial chemotherapy, PCI is effective in decreasing the rate of brain metastasis and improving survival, while the adverse effects is acceptable. There is no significant impact on HRQOL scales during short term. |
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