| 董菲,王晶,王继军,等.全身放射治疗对自体干细胞移植后造血重建的影响及其短期不良反应[J].中华放射医学与防护杂志,2013,33(3):232-234.DONG Fei,WANG Jing,WANG Ji-jun,et al.The analysis of total body irradiation in the hematopoietic reconstitution and short-term side-effects of autologous stem cell transplantation[J].Chin J Radiol Med Prot,2013,33(3):232-234 |
| 全身放射治疗对自体干细胞移植后造血重建的影响及其短期不良反应 |
| The analysis of total body irradiation in the hematopoietic reconstitution and short-term side-effects of autologous stem cell transplantation |
| 投稿时间：2013-01-31 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.03.003 |
| 中文关键词: 全身照射 自体干细胞移植 造血重建 不良反应 |
| 英文关键词:Total body irradiation Autologous peripheral blood stem cell transplantation Hematopoietic reconstitution Side-effects |
| 基金项目:卫生行业科研专项(201002009) |
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| 中文摘要: |
| 目的 探讨自体干细胞移植预处理方案中使用全身放射治疗(TBI)对造血重建的影响及其短期不良反应。方法 对1990-2012年的103例自体干细胞移植患者进行回顾性分析,根据预处理方案不同分为TBI组和NTBI组(不含全身照射),比较两组造血重建的差异,及其相关短期不良反应的异同。结果 两组中性粒细胞植活中位时间均为12 d,TBI组血小板植活中位时间为11 d,而NTBI组为10.5 d,两组间差异无统计学意义,在短期不良反应上TBI组的口腔黏膜炎、胃肠道反应的发生率高于NTBI组(χ2=6.458、22.400,P<0.05),而在感染等方面两组差异无统计学意义。结论 预防治疗后TBI做为预处理方案较NTBI组未见较为严重的短期不良反应,有较好的耐受性。 |
| 英文摘要: |
| Objective To explore the influence of TBI in the conditioning regimen for autologous stem cell transplantation, as well as short-term side-effects. Methods To tally 103 patients were divided into TBI group and no TBI group with autologous stem cell transplantation during 1990-2012. The time required for hematopoietic reconstitution and the short-term side effects were analyzed. Results Between the two groups, the hematopoietic reconstitution time had no significant difference, but there was a high incidence of oral mucositis and gastrointestinal reaction in the TBI group (χ2=6.458,22.400,P<0.05), and the incidence of infection is not significant. Conclusions Given the preventive treatment, the TBI group has no more serious short-term side effects and better tolerance. |
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