| 万伟,董菲,王晶,等.造血生长因子在医源性急性放射病的临床应用[J].中华放射医学与防护杂志,2013,33(3):228-231.WAN Wei,DONG Fei,WANG Jing,et al.Clinical application of cytokines in acute iatrogenic radiation damage[J].Chin J Radiol Med Prot,2013,33(3):228-231 |
| 造血生长因子在医源性急性放射病的临床应用 |
| Clinical application of cytokines in acute iatrogenic radiation damage |
| 投稿时间：2013-01-31 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.03.002 |
| 中文关键词: 细胞因子 造血生长因子 医源性急性放射病 |
| 英文关键词:Cytokine Hematopoietic growth factors Iatrogenic acute radiation disease |
| 基金项目:卫生行业科研专项(201002009) |
|
| 摘要点击次数: 4133 |
| 全文下载次数: 2527 |
| 中文摘要: |
| 目的 探讨造血生长因子对使用全身照射(TBI)进行干细胞移植预处理患者造血重建的影响,进而起到模拟事故性急性放射病,了解细胞因子在急性放射病患者救治中的作用。方法对1990-2012年75例预处理含TBI的造血干细胞移植患者及其供者的造血生长因子应用、植入情况、不良反应发生等进行回顾性分析,了解细胞因子在造血功能重建、造血干细胞动员中的作用以及不良反应。结果 造血干细胞移植患者除1例因预处理不良反应死亡外,其他患者全部恢复造血功能重建。应用rhG-CSF组粒细胞植入的中位时间自体移植为10 d、异基因移植为12 d。自体移植患者应用rhIL-11组与未应用rhIL-11组血小板植入的时间分别为(11.67±1.53)、(13.70±6.27) d。所有TBI患者中口腔溃疡发生率为48%,腹泻发生率为44%。造血重建过程中细胞因子不良反应不明显,动员过程中半数出现轻度不良反应。结论 细胞因子在TBI后造血功能重建以及移植时的造血干细胞动员中起关键作用。 |
| 英文摘要: |
| Objective To explore the influence of hematopoietic growth factors on the TBI patients in the conditioning regimen for stem cell transplantation, and to evaluate the effect of cytokines on treatment of acute radiation disease. Methods The usage of hematopoietic growth factors, implantations and the side-effects of the patients and donors of TBI in the conditioning regimen for stem cell transplantation were retrospectively analysed from 1990 to 2012, and the effect and side-effects of cytokines on the hematopoietic function recovery and stem cell mobilization were observed. Results All patients recovered from their hematopoietic function except one died due to the side-effecs. The median time of white blood cell recover was 10 d in auto-SCT and 12 d in allo-SCT in the G-CSF group. The median day of platelet recovery was 11.67±1.53 in rhIL-11 arm and 13.70±6.27 in no rhIL-11 arm in the auto-SCT group. The incidence rates of dental ulcer and diarrhea in the TBI patients were 48% and 44%, respectively. The occurrence of side-effect was rare in the period of cytokines treatment, but was over 50% during stem cell mobilization. Conclusions Cytokines play very important roles in the hematopoietic function recovery and stem cell mobilization in the TBI patients. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|