| 吴晨彬,吴君心,徐鹭英,等.鼻咽癌调强放疗对海马结构的剂量影响分析[J].中华放射医学与防护杂志,2012,32(3):297-300.WU Chen-bin,WU Jun-xin,XU Lu-ying,et al.Dosimetric study of influence of intensity modulated radiotherapy for nasopharyngeal carcinoma on hippocampal formation[J].Chin J Radiol Med Prot,2012,32(3):297-300 |
| 鼻咽癌调强放疗对海马结构的剂量影响分析 |
| Dosimetric study of influence of intensity modulated radiotherapy for nasopharyngeal carcinoma on hippocampal formation |
| 投稿时间：2011-08-04 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.03.019 |
| 中文关键词: 海马结构 鼻咽癌 调强放疗 |
| 英文关键词:Hippocampal formation Nasopharyngeal carcinoma Intensity modulated radiotherapy |
| 基金项目:福建省医学创新课题(2011-cx-15) |
|
| 摘要点击次数: 5228 |
| 全文下载次数: 3034 |
| 中文摘要: |
| 目的 分析鼻咽癌调强放疗中海马结构的受照剂量及相关影响因素。方法 回顾性分析59例鼻咽癌的调强放疗计划,比较不同临床分期鼻咽癌的海马结构受照剂量及特点。结果 59例鼻咽癌患者的海马结构受照剂量受T分期影响明显,Dmax11.1~78.2 Gy,Dmean 3.2~44.6 Gy,T1~T4期海马结构受照剂量(Dmax和Dmean)差异均有统计学意义,Dmax(F=24.2,P<0.05)、Dmean(F=16.3,P<0.05)。其中T3、T4期病例平均受照剂量和体积明显高于T1、T2期,Dmax、Dmean分别为(58.6±14.8) Gy、(20.9±9.3) Gy和(40.8±9.4) Gy、(12.5±5.1) Gy。结论 鼻咽癌调强放疗中,海马结构可能受到较大剂量的照射,肿瘤T分期是重要的影响因素,特别在T3~4期病例放疗中值得关注。 |
| 英文摘要: |
| Objective To evaluate the dosimetric characteristics of hippocampal formation (HF) in the intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC).Methods Fifty-nine NPC patients underwent IMRT.Simultaneous integrated boost technology was used to determine the doses for the target areas. The dose ranges of the HF were collected by dose-volume histogram. The influence of T stage on the exposure doses (Dmax,Dmean,D20,V10,V20,V30,and V40) were compared.Results The maximum dose for the HF (Dmax) ranged from 11.1 to 78.2 Gy(F=24.2,P<0.05) and the Dmean ranged from 3.2 to 44.6 Gy(F=16.3,P<0.05). The Dmax and Dmean of the T1-2 stage patients were (40.8±9.4) Gy and (12.5±5.1) Gy, respectively, both significantly lower than those of the T3-4 stage patients [(58.6±14.8) Gy, (20.9±9.3) Gy]. The mean exposed volume of the T4 stage patients was significantly larger than that of the T1 and T2 stages patients.Conclusions In the IMRT of NPC, the HF receives rather high irradiation dose. T stage is the main factor influencing the dose, especially T3 and T4 stages deserve serious attention. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|