| 黄利琼,孙志娟,赵永成,王继先.辐射诱发白血病超额相对危险从日本人群向中国人群的转移[J].中华放射医学与防护杂志,2011,31(4):474-477 |
| 辐射诱发白血病超额相对危险从日本人群向中国人群的转移 |
| Transfer of ERR for radiation-related leukemia from Japanese population to Chinese population |
| 投稿时间：2010-11-29 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.04.027 |
| 中文关键词: 超额相对危险 危险转移模型 日本原爆幸存者 寿命研究 白血病 |
| 英文关键词:Excess relative risk Risk transfer model Japanese atomic bomb survivors Life span study Leukemia |
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| 中文摘要: |
| 目的 建立辐射诱发白血病超额相对危险(excess relative risk, ERR)从日本人群向中国人群的转移模型并实施。方法 以相加和相乘加权平均模型作为ERR人群间转移模型;选用《五大洲癌症发病率》第9卷计算两人群白血病基线发病率比值;以1994年发表的白血病亚型别ERR为转移起点,演算辐射诱发白血病ERR从日本人群向中国人群的转移。结果 拟定了一组辐射诱发白血病ERR转移的权重系数:所有类型男性的权重系数为0.4;所有类型女性,以及急性淋巴细胞白血病、急性髓系白血病和慢性髓系白血病双性别的权重系数均为0.3。转移的不确定度采用对数正态分布描述。结论 本研究中的相加和相乘加权平均模型及其权重系数充分考虑了日本人群与中国人群的白血病亚型别基线危险差异,适用于辐射诱发白血病ERR从日本人群到中国人群的转移。 |
| 英文摘要: |
| Objective To establish a transfer model for excess relative risk (ERR) for radiation-related leukemia from Japanese population to Chinese population. Methods Combined ERR of several subtypes of leukemia published in 1994, with the corresponding leukemia baseline incidence rates obtained from Cancer Incidence in Five Continents Vol. IX (CI5-IX) for Japanese population and Chinese population, a weighted risk transfer model was employed between an additive model and a multiplicative model, to execute ERR transfer. Results A range of weighing factors was proposed for risk transfer models: weighing factor was 0.4 for male and 0.3 for female, acute lymphoblastic leukemia, acute myeloid leukemia and chronic myeloid leukemia. The uncertainty for ERR transfer was characterized by lognormal distribution. Conclusions Based on the difference of baseline incidence rate for subtypes of leukemia between Japanese population and Chinese population, the transfer model and these weighing factors discussed in the present study could be applicable to transfer ERR for radiation-related leukemia from Japanese population to Chinese population. |
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