| 傅志超,程惠华,李东石,王凤玫,林贵山.HIF-1α 基因多态性与鼻咽癌放疗敏感性的相关性研究[J].中华放射医学与防护杂志,2011,31(4):430-432 |
| HIF-1α 基因多态性与鼻咽癌放疗敏感性的相关性研究 |
| Genetic polymorphism of HIF-1α G1790A associated with radiosensitivity of nasopharyngeal carcinoma |
| 投稿时间：2010-06-08 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.04.013 |
| 中文关键词: 低氧诱导因子 单核苷酸多态性 鼻咽癌 放射敏感性 |
| 英文关键词:Hypoxia inducible factor 1α Single nucleotidepolymorphism Nasopharyngeal carcinoma Radiosensitivity |
| 基金项目:福建省自然科学基金(2007J0284) |
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| 中文摘要: |
| 目的 研究低氧诱导因子-1α基因(HIF-1α) 第12 外显子1790 (G→A) 单核苷酸多态性与鼻咽癌放疗敏感性的关系。方法 收治的经病理明确诊断、完成根治性放疗、随访3年以上的189例鼻咽癌患者,根据随访结果分为治愈组135例和复发组54例,利用聚合酶链式反应-限制性片段长度多态性PCR-RFLP技术检测HIF-1α 基因第12 外显子1790 (G→A) 的单核苷酸多态性基因型,并分析其基因多态性特征。结果 治愈组和复发组HIF-1α 基因1790 (G→A) 单核苷酸多态性的GG、GA 和AA 基因型频率分别为77.04%、20.74%、2.22%和59.26%、38.89%、1.85%。G、A 等位基因频率分别为87.4%、13.9%和78.7%、21.3%。鼻咽癌复发组HIF-1α基因1790 (G→A) 单核苷酸多态性等位基因分布频率高于治愈组( χ2=6.619,P<0.05) 。结论 HIF-1α 基因1790(G→A)多态性可能与鼻咽癌放射敏感性相关。 |
| 英文摘要: |
| Objective To explore the association between the genetic polymorphism of hypoxia inducible factor 1α (HIF-1α) G1790A and the radiosensitivity of nasopharyngeal carcinoma. Methods A total of 189 patients with nasopharyngeal carcinoma treated with radical radiotherapy were followed-up for 3 years. The patients were divided into cured group with 135 cases and recurrence group with 54 cases by clinical follow-up results. PCR-RFLP was used to determine the mononucleotide genotypes of HIF-1α G1790A. Results The observed genotype frequencies of HIF-1α gene 1790 (G→A) for GG, GA and AA were 70.04%, 20.74%, 2.22% in cured group and 59.26%, 38.89%, 1.85% in recurrence group, respectively. The allele frequencies for G and A were 87.4%, 13.9% in cured groups and 78.7%, 21.3% in recurrence group, respectively, without significant difference in distribution of allele frequencies between the two groups(χ2=6.919,P=0.077). Conclusions The genetic polymorphisms of HIF-1α G1790A might be related with the radiosensitivity of nasopharyngeal carcinoma. |
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