| 徐龙,潘秀颉,杨陟华,曹珍山,朱茂祥.S波段微波长期间歇照射对大鼠内分泌功能的影响[J].中华放射医学与防护杂志,2011,31(3):294-298 |
| S波段微波长期间歇照射对大鼠内分泌功能的影响 |
| Effect of S-band microwave long-term intermittent irradiation on endocrine fuction in rats |
| 投稿时间：2010-03-31 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.03.012 |
| 中文关键词: 微波 血清 内分泌 |
| 英文关键词:Microwave Serum Endocrine |
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| 中文摘要: |
| 目的 研究S波段微波长期间歇照射对大鼠内分泌功能的影响。方法 二级Wistar大鼠雌雄各半,随机分为假照射(对照)和照射组,分别给予4、10和20 mW/cm2照射,每次照射6 min,每周固定2次照射,共照射12周。分别在照射的4、8和12周和停止照射后4周分批活杀,分离血清进行12项内分泌指标检测。结果 S波段微波长期间歇照射后,大鼠血清内分泌有部分指标出现变化。其中雌性大鼠随着照射时间延长,T3水平先降低后上升,10 mW/cm2组在照射8和12周、4及20 mW/cm2组在照射12周均明显升高(t=-2.586、 -2.642、-5.075、-4.365, P <0.05)。FT3变化趋势与T3类似,照射4周时4及10 mW/cm2组雌性大鼠FT3水平明显低于对照组(t=2.275、 2.510, P <0.05),随后升高;照射12周3个照射组均明显高于对照组(t=-2.636, -2.851、-5.240, P <0.05)。TSH在照射4周时降低,其中10 mW/cm2组与对照组相比降低显著(t=2.300, P <0.05),然后升高;20 mW/cm2组在照射8和12周时与对照组相比增高显著(t=-2.838、-3.651, P <0.05)。雄性大鼠皮质醇(COR)及促肾上腺皮质激素(ACTH)呈波动性变化,其中COR的4、10和20 mW/cm2组在照射8周时与对照组相比增高显著(t=-2.772、 -2.234、 -2.505, P <0.05); 20 mW/cm2组在照射12周时与对照组相比降低显著(t=3.067, P <0.05)。雌性大鼠E2在照射4周时略低于对照组,随后升高,10 mW/cm2组在照射8周时、3个照射组在照射12周时与对照组相比增高显著(t=-2.322、-3.179、 -2.655、-4.716, P <0.05);停止照射后4周回复,其中4 mW/cm2组E2水平明显低于对照组 (t=2.250, P <0.05)。雄性大鼠T水平呈先升后降的趋势,10 mW/cm2组在照射8周时与对照组相比增高显著(t=-2.435, P <0.05)。上述指标在停止照射后均有一定程度恢复。结论 S波段微波长期间歇照射可引起大鼠的内分泌功能性损伤。 |
| 英文摘要: |
| Objective To observe the effect of S-band micro-wave long-term intermittent irradiation on endocrine function in rats. Methods A total of 192 rats (male and female) were randomly divided into the sham-irradiation (normal control) groups and the irradiation groups. The irradiation groups were exposed with micro-wave at 3 dosages of 4, 10 and 20 mW/cm2 for 6 min twice a week for 12 weeks, while no administration was given to control group.The endocrine parameters in blood serum were examined by radioimmunoassay at 4,8,12 week during irradiation and 4 week post-irradiation. Results After the irradiation of S-band microwave, parts of the endocrine parameters changed. T3 in famale rats decreased at first and then increased, especially in 10 mW/cm2 group at 8 and 12 week, 20 mW/cm2 group at 4 and 12 week(t=-2.586, -2.642,-5.075,-4.365, P <0.05). FT3 in famale rats had the similar trend as T3, significantly lower in 4 and 10 mW/cm2 groups than that in the control group at 4 week (t=2.275, 2.510, P <0.05), then increased, especially in three irradiation groups at 12 week (t=-2.636, -2.851,-5.240, P <0.05). TSH decreased at 4 week, especially in 10 mW/cm2 group (t=2.300, P <0.05); and then increased in the irradiation groups at 20 mW/cm2 at 8 and 12 week (t=-2.838,-3.651, P <0.05). COR and ACTH in male rats showed changes in volatility, in which the 4,10 and 20 mW/cm2 groups at 8 week increased significantly (t=-2.772, -2.234, -2.505, P <0.05), while 20 mW/cm2 group at 12 week decreased significantly (t=3.067, P <0.05). E2 in female rats was slightly lower in irradiation groups at 4 week than the control group, then increased, especially in 10 mW/cm2 group at 8 week, three irradiation groups at 12 week (t=-2.322,-3.179, -2.655,-4.716, P <0.05),and returned to the normal at 4 week post-irradiation, significantly lower in 4 mW/cm2 group than that in the control group (t=2.250, P <0.05). T in male rats increased first and then decreased, especially in 10 mW/cm2 group at 8 week(t=-2.435, P <0.05). After exposure the above indexes restored to some extent. Conclusions The long-term intermittent irradiation of S-band microwave can cause adverse effects on the endocrine function of rats. |
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