| 申戈,王芳,张伟京,刘兵,袁顺宗,王莉,邵云.间充质干细胞治疗小鼠放射性肺损伤的病理学研究[J].中华放射医学与防护杂志,2010,30(6):670-673 |
| 间充质干细胞治疗小鼠放射性肺损伤的病理学研究 |
| Mesenchymal stem cells reduce the irradiation induced lung injury |
| 投稿时间：2010-02-11 |
| DOI： |
| 中文关键词: 放射性肺损伤 间充质干细胞 小鼠骨实质 小鼠胚胎背主动脉 |
| 英文关键词:Irradiation induced lung injury Mesenchymal stem cells Mouse bone Mouse embryos dorsal aorta area |
| 基金项目:国家自然科学基金 (30972974) |
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| 中文摘要: |
| 目的 观察骨实质间充质干细胞及小鼠胚胎背主动脉(dorsal aorta,DA)区间充质干细胞对小鼠肺损伤的治疗作用。方法 将C57BL/6小鼠分为4组:正常对照组、肺照射组、骨片来源MSCs治疗组和胚胎背主动脉区来源MSCs治疗组。9个月后观察肺组织结构的病理变化。结果 小鼠肺纤维化及肺泡炎评分,正常组评0.17分、肺照射组评2分、胚胎背主动脉区MSCs治疗组评1分、骨片MSCs治疗组评1.38分,在骨片来源MSCs治疗组及胚胎背主动脉区来源MSCs治疗组均较肺照射组轻,由于例数少,未做统计分析。结论 无论是骨片来源还是胚胎背主动脉来源的MSCs,均有减轻放射性肺损伤的作用。 |
| 英文摘要: |
| Objective To evaluate the role of mesenchymal stem cells (MSCs) derived from mouse bone and embryo dorsal aorta(DA)area in the treatment of irradiation induced lung injury of mouse model. Methods The mice were divided into four groups as normal control group, irradiation group, bone MSCs treatment group and DA MSCs treatment group. Immunohistochemical Analysis of lung tissue was observed after 9 months of treatment. Results Fibrosis and alveolar infiltration were scored in each group. The score for fibrosis and alveolar is 0.17 in normal control group, 2 in irradiation group, 1 in bone MSCs treat group and 1.38 in DA MSCs treat group. Conclusion The extent of irradiation Induced Lung Injury could be reduced thorough the treatment of MSCs derived from mouse bone and embryos dorsal aorta(DA)area. |
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