| 汪传高,汪黎,周平坤,王仲文,胡永哲,靳海明,张学清,陈英.香兰素衍生物VND3207对小鼠骨髓细胞遗传损伤的防护效应研究[J].中华放射医学与防护杂志,2010,30(5):558-560 |
| 香兰素衍生物VND3207对小鼠骨髓细胞遗传损伤的防护效应研究 |
| Radiological protection effect of vanillin derivative VND3207 against radiation-induced cytogenetic damage in mouse bone marrow cells |
| 投稿时间：2010-02-03 |
| DOI： |
| 中文关键词: 香兰素衍生物 γ射线 嗜多染红细胞微核 染色体畸变 有丝分裂指数 辐射防护剂 |
| 英文关键词:Vanillin derivative γ-ray Polychromatophilic erythroblasts micronuclei Chromosome aberration Mitotic index Radioprotective agent |
| 基金项目:国家自然科学基金杰出青年基金(C30825011) |
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| 中文摘要: |
| 目的 研究香兰素衍生物4-羟基-3,5-二甲氧基苯甲醛(VND3207)对γ射线整体照射小鼠骨髓细胞遗传损伤的防护作用。方法 BALB/c小鼠按10、50和100 mg/kg不同剂量灌胃给药,1次/d,连续5 d,最后一次给药后2 h, 2 Gy 60Co γ射线照射,照射后48 h观察小鼠骨髓嗜多染红细胞微核、染色体畸变和骨髓有丝分裂指数的改变。结果 不同剂量(10、50和100mg/kg)的VND3207均能有效地降低小鼠骨髓嗜多染红细胞微核率(t=2.40～4.26,P<0.05)和染色体畸变率(t=2.36～3.52,P<0.05),同时提高骨髓有丝分裂指数。药物保护效果与给药剂量呈依赖关系,其中100 mg/kg剂量组的微核率和染色体畸变率与单纯照射组相比,分别降低了65%和50%。结论 VND3207对60Co γ射线诱发的小鼠骨髓辐射损伤有良好的保护作用。 |
| 英文摘要: |
| Objective To study the protection of vanillin derivative VND3207 on the cytogenetic damage of mouse bone marrow cell induced by ionizing radiation. Methods BALB/c mice were randomly divided into five groups:normal control group, 2 Gy dose irradiation group, and three groups of 2 Gy irradiaiton with VND3207 protection at doses of 10, 50 and 100 mg/kg, respectively. VND3207 was given by intragastric administration once a day for five days. Two hours after the last drug administration, the mice were irradiated with 2 Gy γ-rays. The changes of polychromatophilic erythroblasts micronuclei (MN), chromosome aberration (CA) and mitosis index (MI) of mouse bone marrow cells were observed at 24 and 48 h after irradiation. Results Under the protection of VND3207 at the dosages 10, 50, 100 mg/kg, the yields of poly-chromatophilic erythroblasts MN and CA of bone marrow cells were significantly decreased(t=2.36-4.26,P<0.05), and the marrow cells MI remained much higher level compared with the irradiated mice without drug protection(t=2.58,2.01,P<0.05). The radiological protection effect was drug dose-dependent, and the administration of VND3207 at the dosage of 100 mg/kg resulted in reduction by 50% and 65% in the yields of MN and CA, respectively. Conclusions VND3207 had a good protection effect of on γ-ray induced cytogentic damage of mouse bone marrow cells. |
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