| 梁莉,张淑兰,贾廷珍,刘青杰,马力文,苏旭,张照辉,秦斌,陈森,王文学.山西忻州事故中宫内受照胎儿出生后第16年随访[J].中华放射医学与防护杂志,2010,30(5):520-522 |
| 山西忻州事故中宫内受照胎儿出生后第16年随访 |
| Follow-up of victim exposed in uterus 16 yearsafter Xinzhou radiation accident |
| 投稿时间：2010-04-13 |
| DOI： |
| 中文关键词: 放射性损伤 宫内照射 生长发育 智力发育 放射性肿瘤 |
| 英文关键词:Radiation injury Radiation exposure in uterus Growth and development Intelligence development |
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| 中文摘要: |
| 目的 随访1992年11月山西忻州辐射事故中意外受到60Co 源照射的妊娠妇女"芳"所产女婴"京"的生长发育情况,以观察研究宫内照射的远期效应及其现实意义。方法 除了进行一般医学检查外,应用染色体畸变分析方法和荧光原位杂交(FISH)方法检测染色体非稳定性畸变率和稳定性畸变率,中国修订韦氏儿童智力量表(C_WISC)检测智商水平。结果 无恶性肿瘤及遗传性疾病家族史;"京"易感冒,但无其他疾患;月经和体格发育正常;不能进行简单数字加减运算,但可进行简单语言交流和写作等。常规实验室检查果均正常。染色体未见非稳定性畸变;FISH检测显示,染色体易位率为2.3%,提示染色体损伤剂量为0.61 Gy,推算"京"当年受到辐射的生物剂量为1.85 Gy。超声检查示结节性甲状腺肿。中国修订韦氏儿童智力量表(C_WISC)测验结果显示言语、操作和全量表智商分别为51、50和46,总智力优于0.01%的人群,低于99.90%的人群。结论宫内受照未影响"京"出生后的体格发育,对其智力发育有严重影响;目前尚无恶性肿瘤的证据。 |
| 英文摘要: |
| Objective To observe and study the late effects of intrauterine exposure to irradiation. Methods A 16-year-old girl, borne by a woman exposed to 60Co irradiation during the Xinzhou radiation accident 16 years ago underwent inquiry, general medical examination. Conventional chromosome aberration analysis and fluorescence in situ hybridization (FISH) were used to examine non-stability and stability chromosome aberrations, and China revised Wechsler Intelligence Scale for Children (C_WISC) was used to detect IQ level. Results Inquiry revealed no history of carcinoma and no family history of hereditary diseases. The girl often caught cold when she was a child, but she hadn’t any other diseases. Menarche occurred when she was 12 years old, and she had not suffered from dysmenorrhea. Her development of body frame constitution was normal. She could not carry out addition and subtraction, but she could make simple verbal communication, writing and even reciting text. The results of the routine lab examination were within the normal range. Unstable chromosome aberrations were not shown, and the chromosome translocation rate was 2.3%. The dose that induced the chromosome injury was deduced as 0.81 Gy. The biological dose of the radiation that she was exposed to was inferred to be 1.85 Gy when she was in ther mothers uterus. Ultrasonic sound showed nodular goiter and no malignant change. Chinas revised Wechsler Intelligence Scale for Children (C_WISC) test results showed that speech, operation and full-scale IQ was 51, 50, and 46 respectively. The total intelligence was better than 0.01%, and worse than 99.90% of the population. Conclusions Exposure in utero does not affect the body frame constitution development after birth of the fetus, but mental retardation is clear. No evidence of any tumor can be found for the children exposed to radiation before their birth. |
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