| 宋铁砾,郑磊,张杰,蔡志刚,杨朝晖,俞光岩,张建国.125I粒子腮腺区组织间近距离治疗对面神经功能恢复的影响[J].中华放射医学与防护杂志,2010,30(4):436-438 |
| 125I粒子腮腺区组织间近距离治疗对面神经功能恢复的影响 |
| Influence of 125I seed interstitial brachytherapy on recovery of facial nerve function |
| 投稿时间：2009-08-11 |
| DOI：10.3760/cma.j.issn.0254-5098.2010.04.017 |
| 中文关键词: 125I 粒子 House-Brackmann(HB)评价 神经肌电图(ENoG) 传导潜伏时 |
| 英文关键词:125I seed House-Brackmann grading scales Electroneurography(ENoG) Latency time (LT) |
| 基金项目:首都医学科研发展基金(2005-2006) |
|
| 摘要点击次数: 3212 |
| 全文下载次数: 2012 |
| 中文摘要: |
| 目的 研究125I粒子腮腺区组织间近距离治疗对面神经功能恢复的影响。方法 对无面瘫的21例腮腺原发癌患者,采用外科手术切除(保存面神经),术后1周行125I放射性粒子腮腺区组织间治疗,粒子活度24.05×106~25.9×106 Bq,处方剂量60 Gy。应用House-Brackmann(HB)评价系统和面神经肌电图对患者分别进行主观评价和客观评价,随访时间4年。按照面神经功能分区评价的方法,以神经传导潜伏时为指标,将患侧面神经分为异常组和正常组,分别与健侧相应面神经分支进行比较。结果 所有患者术后均出现不同程度面瘫,随访术后6个月内均恢复至术前正常水平;面神经患侧异常组与健侧对应神经分支传导潜伏时的差异在术后1周至术后6个月具有统计学意义( t= 2.362, P= 0.028),患侧较健侧明显延长,而术后1~4年差异无统计学意义;面神经患侧正常组与健侧对应分支神经传导潜伏时的差异在术后1周具有统计学意义( t=2.522, P=0.027 ),患侧较健侧延长,而术后2月~4年差异无统计学意义。结论 125I 粒子组织间近距离治疗不影响腮腺癌术后面神经功能的临床恢复,对面神经无迟发损害。 |
| 英文摘要: |
| Objective To study the influence of 125I seed interstitial brachytherapy in parotid region on the recovery of facial nerve function. Methods A total of the data of 21 patients with primary parotid carcinoma were treated with resection and 125I interstitial brachytherapy. All the patients had no facial palsy before operation and the prescribed dose was 60 Gy. During 4 years of follow-up, the House-Brackmann grading scales and ENoG were used to evaluate the function of facial nerve. According to the modified regional House-Brackmann grading scales, the facial nerve branches of patients in affected side were divided into normal and abnormal groups, and were compared with those in contra-lateral side. Results Post-operation facial palsy occurred in all the patients, but the facial palsy recovered within 6 months. The latency time differences between affected side and contralateral side were statistically significant in abnormal group from 1 week to 6 months after treatment( t =2.362, P =0.028), and were also different in normal group 1 week after treatment( t =2.522, P =0.027). Conclusions 125I interstitial brachytherapy has no influence on recovery of facial nerve function after tumor resection and no delayed facial nerve damage. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|