| 邰国梅,张军宁,王建平,王宜宗.XRCC1单核苷酸多态性与鼻咽癌放疗近期 疗效的相关性分析[J].中华放射医学与防护杂志,2009,29(6):608-610 |
| XRCC1单核苷酸多态性与鼻咽癌放疗近期 疗效的相关性分析 |
| Relationship between polymorphisms of XRCC1 and the short-term effect of radiotherapy of nasopharygeal carcinoma |
| 投稿时间：2008-12-20 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.06.015 |
| 中文关键词: XRCC1 单核苷酸多态 鼻咽癌 放射治疗 |
| 英文关键词:XRCC1 Polymorphisms Nasopharygeal carcinoma Radiotherapy |
| 基金项目: |
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| 摘要点击次数: 2888 |
| 全文下载次数: 2019 |
| 中文摘要: |
| 目的 探讨XRCC1单核苷酸多态性与鼻咽癌放疗敏感性的关联性。 方法 放疗前采鼻咽癌患者静脉血,用多聚链酶反应-高温连接酶反应(PCR-LDR)进行XRCC1Arg399Gln基因的分型,观察各型放疗中及放疗后3个月的疗效。结果 放疗中期Gln/Gln基因型的肿瘤退缩率为0.855±0.026,显著高于Arg/Gln基因型的0.386±0.183和Arg/Arg基因型的0.377±0.169,差异有统计学意义( F =11.16, P =0.0003);XRCC1 Codon399Gln/Gln型放疗后3个月CR达100%,Arg/Gln型为76.2%,Arg/Arg型为66.7%,三者差异无统计学意义。结论 XRCC1Codon399基因型可以预测鼻咽癌放疗中期的局部疗效。 |
| 英文摘要: |
| Objective To find the intrinsic influencing factor of radiosensitivity, and to detect the polymorphisms of XRCC1 of the patients suffering from nasopharygeal carcinoma(NPC) and the different short-term curative effect of radiotherapy. Methods XRCC1 Codon Arg399Gln was determined by polymerase chain reaction and ligase detection reaction(PCR-LDR), and the effect of radiotherapy of NPC on mid-therapy and 3 months after finishing radiation were observed. Results On mid-radiotherapy, the retraction rate of Gln/Gln genotype was 0.855±0.026, which was higher than that of Arg/Gln (0.386±0.183) and Arg/Arg genotypes (0.377±0.169) ( F = 11.16, P = 0.0003). The CR rate of 3 months after radiotherapy of the case with Gln/Gln was 100%, Arg/Gln was 76.2%, Arg/Arg was 66.7% ( P >0.05). Conclusion Polymorphisms of XRCC1Arg399Gln could be a predictor for the radiotherapy effect of NPC on mid-radiotherapy. |
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