中华放射医学与防护杂志

郭隆佳,陈志坚,陈创珍,等.食管鳞癌细胞HIF-1α和COX-2表达及肿瘤组织微血管密度的临床意义研究[J].中华放射医学与防护杂志,2009,29(5):502-505.GUO Long-jia,CHEN Zhi-jian,CHEN Chuang-zhen,et al.Expressions of HIF-1α and COX-2 in esophageal squamous cell carcinoma and their correlation with intratumoral MVD[J].Chin J Radiol Med Prot,2009,29(5):502-505

食管鳞癌细胞HIF-1α和COX-2表达及肿瘤组织微血管密度的临床意义研究

Expressions of HIF-1α and COX-2 in esophageal squamous cell carcinoma and their correlation with intratumoral MVD

投稿时间：2008-11-04

DOI：

中文关键词: 食管肿瘤 HIF-1α COX-2 微血管密度放射治疗预后

英文关键词:Esophageal carcinoma HIF-1α COX-2 Microvascular density Radiotherapy Prognosis

基金项目:

作者	单位	E-mail
郭隆佳	515031 汕头, 广东省汕头大学医学院附属肿瘤医院放疗科
陈志坚	515031 汕头, 广东省汕头大学医学院附属肿瘤医院放疗科	zjchenmd@stu.edu.cn
陈创珍	515031 汕头, 广东省汕头大学医学院附属肿瘤医院放疗科
洪超群	515031 汕头, 广东省汕头大学医学院附属肿瘤医院病理科
吴晓	515031 汕头, 广东省汕头大学医学院附属肿瘤医院病理科

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中文摘要:

目的研究食管鳞癌细胞HIF-1α和COX-2的表达和肿瘤微血管密度(MVD)与食管癌放疗疗效的关系。方法应用免疫组织化学二步法对55例食管鳞癌食管镜活检组织中HIF-1α、COX-2的表达进行检测,并用同样方法检测癌组织中 CD34的表达评估MVD。分析其与临床病理学参数及放疗疗效的关系。结果 HIF-1α和COX-2的阳性表达率分别为92.7%和69.1%,MVD为2~29条/高倍视野,平均为(11.2±4.1)条。HIF-1α和COX-2的表达水平与MVD数量无关。HIF-α和COX-2的表达水平与肿瘤的细胞分化程度、肿瘤部位均无关。单因素分析示食管癌放疗后近期疗效中位生存期和2年生存率与HIF-1α、COX-2表达及MVD无关。结论食管鳞癌组织中HIF-1α和COX-2的表达情况和肿瘤组织中微血管密度无关。 HIF-1α和COX-2 的表达水平及MVD均不能作为食管鳞癌放射治疗的预后指标。

英文摘要:

Objective To investigate the expressions of HIF-1α,COX-2 and introtumoral microvascular density(MVD) in esophageal squamous cell carcinoma (ESCC),and their impacts on the efficacy of radiotherapy. Methods Expressions of HIF-1α and COX-2 were assessed by immunohistochemistry methods in fifty-five cases of ESCC.Microvessels were labelled in sections of same tissues by CD34 immunohistochemistry.The correlations with clinicopathological features and postradiotherapy survival rates were evaluated and analyzed.Results The MVD ranged from 2 to 29(mean of 11.2±4.1). The positive rates of HIF-1α and COX-2 protein expression were 92.7% and 69.1%, respectively, both of which were not correlated with intratumoral MVD. The expressions of HIF-1α and COX_2 were not correlated with histological grade or the location of the primary tumor. Univariate analysis revealed that 2_year survival rates and median survival time following radiotherapy were not assocaited with the expressions of HIF_1α, COX_2 or MVD. Conclusions MVD and the expressions of HIF-1α and COX-2 in ESCC are not efficient to predict the outcome of ESCC following radiotherapy.

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