| 沈捷,张福泉,邱杰,等.局限期小细胞肺癌两种放射治疗技术的剂量学比较[J].中华放射医学与防护杂志,2009,29(4):397-400.SHEN Jie,ZHANG Fu-quan,QIU Jie,et al.Dosimetric comparison of conventional and three-dimensional radiotherapy techniques for limited-stage small cell lung cancer[J].Chin J Radiol Med Prot,2009,29(4):397-400 |
| 局限期小细胞肺癌两种放射治疗技术的剂量学比较 |
| Dosimetric comparison of conventional and three-dimensional radiotherapy techniques for limited-stage small cell lung cancer |
| 投稿时间：2009-04-24 |
| DOI： |
| 中文关键词: 局限期小细胞肺癌 三维适形放射治疗 常规放射治疗 剂量体积直方图 |
| 英文关键词:Limited-stage small cell lung cancer Three dimensional conformal radiotherapy Conventional radiotherapy Dose volume histograms |
| 基金项目:北京协和医院霍英东专项研究基金 |
| 作者 | 单位 | E-mail | | 沈捷 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院放疗科 | | | 张福泉 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院放疗科 | zhangfuquan3@sina.com | | 邱杰 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院放疗科 | | | 杨波 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院放疗科 | | | 庞廷田 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院放疗科 | | | 许艳珍 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院放疗科 | |
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| 中文摘要: |
| 目的 探讨2种不同的放射治疗技术治疗局限期小细胞肺癌时,对靶区和危及器官物理剂量学的影响。 方法 回顾性分析10例局限期小细胞肺癌患者。每例患者在总疗程中需重新定位1次,2个阶段中每阶段均制定常规放疗和三维适形放疗计划(均采用Cadplan R 3.1.2治疗系统)。总剂量为50 Gy。用剂量体积直方图评价2个阶段靶区和危及器官的剂量参数。 结果第1阶段治疗适形放疗在计划靶体积1(PTV1)的均匀指数(HI) 值、PTV2的适形指数(CI)值、健肺的V30和健肺的平均剂量上优于常规放疗。第2阶段治疗适形放疗在PTV1的CI值、平均剂量、HI值优于常规放疗,PTV2的CI值、平均剂量上也优于常规放疗。 结论 三维适形放射治疗的优势在于更好的满足CI和HI,但对于危及器官的保护上与常规放疗无明显区别。 |
| 英文摘要: |
| Objective To compare the dosimetric difference in planning target volume (PTV) and organ at risk (OAR) with conventional and the three-dimensional treatment planning for limited-stage small cell lung cancer. Methods Ten patients with limited-stage small cell lung cancer were chosen in the present study. Two treatment planning were designed twice respectively with the Cadplan R 3.1.2 treatment planning system for each patient in two-course. The total radiation dose was 50 Gy. The dosimetric parameters were assessed with dose volume histograms in PTV and OAR. Results For the first course, the dose homogeneity indices(HI)of PTV1, conformal indices(CI) of PTV2, contralateral lung V30 and contralateral mean lung dose in the three-dimensional treatment planning were better than that in the conventional treatment planning. For the second course, the HI, CI and mean dose of PTV1, CI and mean dose of PTV2 in the three-dimensional treatment planning were better than that in the conventional treatment planning. Conclusions By comparison with conventional treatment planning, the three-dimensional conformal treatment planning could meet the demands of dosimetric requirements well for limited-stage small cell lung cancer with three-dimensional conformal radiotherapy, but with no significant dosimetric differences in the OAR. |
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