| 洪梅,姜藻,聂岩,周迎峰.热疗对食管癌放疗患者T辅助细胞亚型的影响[J].中华放射医学与防护杂志,2009,29(1):39-40 |
| 热疗对食管癌放疗患者T辅助细胞亚型的影响 |
| Influence of hyperthermo-radiotherapy on T helper subgroup for patients with esophageal carcinoma |
| 投稿时间：2008-05-28 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.01.011 |
| 中文关键词: 食管癌 热疗 放射治疗 T辅助细胞亚型 |
| 英文关键词:Esophageal carcinoma Hyperthermia Radiotherapy T helper subgroup |
| 基金项目:南京市卫生局医学科技发展基金项目(Ykk05114) |
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| 中文摘要: |
| 目的 探讨热疗对食管癌放疗患者T辅助细胞亚型(Th1/Th2)的影响。方法 22例患者随机分2组:单放组10例,常规放疗,总剂量 64~66 Gy,5次/周,共30~33次;综合组12例,除常规放疗外加内生场热疗,2次/周,4~5周。流式细胞仪检测治疗前、后患者外周血Th1/Th2。结果单放组治疗后Th1细胞显著下降(t=5.33,P<0.01);综合组治疗后Th1细胞没有明显变化(t=-1.41, P>0.05)。组间比较:单放组Th1细胞下降(t=4.28,P<0.05)。结论 内生场热疗促使机体由Th2细胞向Th1细胞逆转,调整Th1/Th2细胞平衡。 |
| 英文摘要: |
| Objective To evaluate the influence of hyperthermia on T helper subgroup (T help type1/T help type2,Th1/Th2) for patients with esophageal carcinoma.Methods 22 patients of esophageal carcinoma were randomly divided into two groups. Both group patients were treated by external radiation, the total dose was 64-66 Gy/30-33 fractions. Radiotherapy was the only therapy method in group A. Hyperthermia was used twice every week, with 8-10 fractions except for radiotherapy in group B. All patients were phlebotomized at the beginning and the end of radiotherapy for examining Th1/Th2 by flow cytometry.Results Th1 was significantly decreased in group A(t=5.33,P<0.01). All indexes in group B had no difference (t=-1.41, P>0.05). The Th1 in group A was decreased much more than that in group B(t=4.28,P<0.05).Conclusion Hyperthermia could rectify the balance of Th1/Th2. |
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