中华放射医学与防护杂志

夏广荣,刘桂梅,靳国华,等.肺癌骨转移放疗止痛效果临床分析[J].中华放射医学与防护杂志,2008,28(3):262-264.XIA Guang-rong,LIU Gui-mei,JIN Guo-hua,et al.Clinical study of radiotherapy in bone metastases of lung cancer[J].Chin J Radiol Med Prot,2008,28(3):262-264

肺癌骨转移放疗止痛效果临床分析

Clinical study of radiotherapy in bone metastases of lung cancer

投稿时间：2007-11-26

DOI：

中文关键词: 肿瘤骨转移止痛放射疗法治疗结果

英文关键词:Neoplasms Bone metastases Pain relief Radiotherapy Outcome

基金项目:

作者	单位
夏广荣	101149, 北京结核病胸部肿瘤研究所北京胸科医院放疗科
刘桂梅	101149, 北京结核病胸部肿瘤研究所北京胸科医院放疗科
靳国华	101149, 北京结核病胸部肿瘤研究所北京胸科医院放疗科
李雪冰	北京结核病胸部肿瘤研究所北京胸科医院放疗科, 综合科

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中文摘要:

目的分析骨转移癌放疗止痛疗效。方法将189例原发灶为肺癌的骨转移癌计221个病灶的放疗结果进行回顾性分析。放疗方案分为2种剂量分割组:(1)常规分割组:2Gy/次,5次/周,总剂量30～50Gy,共163个病灶;(2)中～低分割组:3～5Gy/次,2～3次/周,总剂量20～40Gy,共58个病灶。对不同病理类型和原发灶控制情况下的放疗结果进行分层分析。结果常规分割、中-低分割组有效率分别为90.7%和87.9%(χ²=1.229,P>0.05),总有效率为90.0%。小细胞癌、非小细胞肺癌的有效率分别为92.4%和89.0%(χ²=0.668,P>0.05)。原发灶控制与未控制的有效率为88.4%和91.7%(χ²=0.787,P>0.05)。结论放疗是一种有效止痛方式,可作为骨转移癌首选治疗方法。不同分割剂量放疗对骨转移疼痛的缓解程度无影响,放疗疗效与原发灶病理类型及原发灶控制与否关系不明显。

英文摘要:

Objective To evaluate the efficacy of radiotherapy on bone metastases of lung cancer. Methods 189 patients with painful bone metastasis were investigated retrospectively from January 2000 to November 2006. There were two radiotherapy groups in this study. Conventional fractionation group was 2 Gy/fraction/day, 5 days/week to 30-50Gy,including 163 tumors. The middle fractionation and hypofraction group was 3-5Gy/fraction/day, 2-3 days/ week to 20-40Gy, including 58 tumors. Subgroup analysis were used for radiotherapy responses according to pathologic type and primary tumor control status. Results The response rates were 90.7% and 87.9% (χ²=1.229, P>0.05), respectively, in conventional fractionation, middle fractionation and hypofractionation groups while the overall response rate was 90.0%. In subgroup analysis, the response rates were 92.4% and 89.0% (χ²=0.668, P>0.05), respectively in small cell lung cancer and non- small cell lung cancer. The response rates were 88.4% and 91.7% (χ²=0.787,P>0.05) in controlled primary tumor and not controlled primary tumor subgroups. Conclusions Radiotherapy is effective and could be the first option that can relieve bone pain in bone metastasis of lung cancer. However, different dose-fractionation, different pathologic type and primary tumor control status have no significant impact on effect of radiotherapy.

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