中华放射医学与防护杂志

蔡勇,李东明,孙艳,等.甘氨双唑钠对恶性肿瘤放射增敏的临床研究[J].中华放射医学与防护杂志,2008,28(3):260-261.CAI Yong,LI Dong-ming,SUN Yan,et al.Clinic study of CMNa radiosensitivity enhacement on malignant tumors[J].Chin J Radiol Med Prot,2008,28(3):260-261

甘氨双唑钠对恶性肿瘤放射增敏的临床研究

Clinic study of CMNa radiosensitivity enhacement on malignant tumors

投稿时间：2007-10-29

DOI：

中文关键词: 甘氨双唑钠放射治疗恶性肿瘤

英文关键词:CMNa Radiotherapy Malignant tumors

基金项目:

作者	单位
蔡勇	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科
李东明	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科
孙艳	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科
苏星	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科
刘长青	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科
肖绍文	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科
铁剑	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科
徐博	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科
张珊文	100036 北京大学临床肿瘤学院北京肿瘤医院放疗科

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中文摘要:

目的评价甘氨双唑钠(sodium glycididazole, CMNa)在恶性肿瘤的放射增敏作用及安全性。方法对符合CMNa Ⅳ期临床研究的80例诊断明确的实体瘤患者采用三维适形放疗(three dimensional conformal radiotherapy, 3D-CRT)或常规放疗,2 Gy/次,5次/周,中位照射剂量60Gy,同期应用CMNa 800 mg/m²,每周3次;观察肿瘤近期疗效和毒性作用。结果宫颈癌的近期疗效最好,有效率91.7%,其后依次是鼻咽癌85.7%、食管癌66.7%、肺癌54.5%、肝胆癌40%,全部有效率(CR+PR)62.6%,疾病控制率(CR+PR+SD)达到100%;黏膜、皮肤的不良反应最常见,但多为1～2级轻度反应,分别为51.3%和46.3%;血液毒性白细胞下降最明显,但与治疗前相比差异无统计学意义(χ²=3.329,P=0.061),对肝肾功能、心电图变化均无明显影响。结论放疗结合CMNa治疗恶性肿瘤有满意的近期疗效,无明显毒性反应。

英文摘要:

Objective To evaluate the effects and safety of CMNa on radiosensitivity enhacement for malignant tumors. Methods According to the standard protocol of CMNa Ⅳ stage clinic trial, 80 patients with malignant tumors were treated with 3DCRT or conventional radiotherapy, 2 Gy/fraction and five fractions weekly. Concomitance CMNa were applied in intravenous 800 mg/m², three times weekly. The treatment effects and side-effects were observed. Results The curative effect rates were 91.7% for cervical cancer, 85.7% for nasopharynx cancer, 66.7% for esophageal cancer, 54.5% for lung cancer, 40% for liver and gall cancer. The total curative effect rate was 62.6% and the tumor control rate was 100%. The side-effects occurrence rates of mucosa and skin which were grades 1 to 2, were 51.3% and 46.3%,respectively,which were the highest in all side-effects. There were no statistical significances between before and after treatment on the side-effects and blood test. Conclusions CMNa combined with radiotherapy can enhance the control rates of tumors with low toxicity and high safety.

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