| 张明,高献书,张春丽,等.外照射联合131I-chTNT对小鼠Lewis瘤影响的研究[J].中华放射医学与防护杂志,2008,28(3):255-257.ZHANG Ming,GAO Xian-shu,ZHANG Chun-li,et al.Effect of irradiation combined with 131I-chTNT on Lewis tumor of mice[J].Chin J Radiol Med Prot,2008,28(3):255-257 |
| 外照射联合131I-chTNT对小鼠Lewis瘤影响的研究 |
| Effect of irradiation combined with 131I-chTNT on Lewis tumor of mice |
| 投稿时间：2008-03-05 |
| DOI： |
| 中文关键词: 小鼠 Lewis瘤 照射 131I-chTNT |
| 英文关键词:Mice Lewis tumor Irradiation 131I-chTNT |
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| 中文摘要: |
| 目的 研究外照射联合131I-chTNT对荷瘤小鼠肿瘤生长的影响,并观察其在小鼠体内的分布和显像。方法 建立C57小鼠Lewis瘤模型,肿瘤直径达一定大小时随机分组进行实验。测量给药后不同时间肿瘤组织及感兴趣器官的放射性,观察活体显像情况及荷瘤小鼠肿瘤生长延迟效应。结果 联合外照射组肿瘤组织的放射性1、3和5d均高于单药组,组间差异有统计学意义(P值分别为0.018、0.041和0.024),两组中正常组织的放射性差别无统计学意义(P＞0.05)。联合组肿瘤区核素显像比单药组强且持续时间长。肿瘤生长效应实验中单药组、外照射组、联合组的绝对延迟时间为3.1、9.1和13.1d,标准化延迟时间为10d,131I-chTNT对放射的增益因子为1.08。结论外照射联合131I-chTNT后可促进其在小鼠体内肿瘤区的浓聚,而对正常组织无影响。联合应用131I-chTNT可提高外照射对荷瘤小鼠的放射效应。 |
| 英文摘要: |
| Objective To investigate the biodistribution and scintigraphy of Lewis carcinoma of mice with 131I-chTNT combined with or without irradiation, and to study the effects on the tumor growth of mice. Methods When the tumor size in C57 mice bearing Lewis carcinoma in the right leg was big enough, the mice were randomly divided into different groups to receive different treatment. The biodistribution and scintigraphy of 131I-chTNT were observed at various time after tail-intravenous injection in tumor-bearing mice. The effect of treatment was assessed by tumor growth delay. Results The uptake of 131I-chTNT in tumor tissue was significantly higher in combined group than in 131I-chTNT group (P＜0.05) and there were no more side effects in the combined group(P＞0.05). The scintigraphy result showed higher tumor accumulation of 131I-chTNT in combined group than that in 131I-chTNT group. The absolute growth delay for irradiation group, 131I-chTNT group and the combined group was 9.1, 3.1 and 13.1 days, respectively. The nominal growth delay was 10 days, and the enhancement factor of 131I-chTNT for RT was 1.08. Conclusions 131I-chTNT combined with irradiation can increase the uptake of 131I-chTNT in tumor without side effects. 131I-chTNT can enhance the radiotherapeutic effect for tumor-bearing mice. |
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