中华放射医学与防护杂志

刘青杰,封江彬,陆雪,等.包钢选矿厂含钍粉尘作业工人外周血淋巴细胞适应性反应的研究[J].中华放射医学与防护杂志,2008,28(3):235-238.LIU Qing-jie,FENG Jiang-bin,LU Xue,et al.Adaptive responses on chromosome aberration and DNA breakage of peripheral lymphocytes from workers exposed to thorium and rare earth mixed dust in Baotou Steel Plant[J].Chin J Radiol Med Prot,2008,28(3):235-238

包钢选矿厂含钍粉尘作业工人外周血淋巴细胞适应性反应的研究

Adaptive responses on chromosome aberration and DNA breakage of peripheral lymphocytes from workers exposed to thorium and rare earth mixed dust in Baotou Steel Plant

投稿时间：2007-06-12

DOI：

中文关键词: 含钍粉尘染色体畸变单细胞凝胶电泳适应性反应

英文关键词:Thorium and rare earth mixed dust Chromosome aberration Single cell gel electrophoresis Adaptive response

基金项目:

作者	单位	E-mail
刘青杰	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所
封江彬	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所
陆雪	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所
陈德清	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所
刘玉飞	包钢劳动卫生职业病防治研究所
贾柯君	包钢劳动卫生职业病防治研究所
吕慧敏	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所
苏旭	100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所	suxu@nirp.cn

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中文摘要:

目的探索低剂量天然放射性钍是否诱导出职业人员的外周血淋巴细胞适应性反应。方法选择包钢选矿厂含钍粉尘作业工人(暴露组)和对照人员各20例,采集外周静脉血,分析染色体畸变。同时,对采集的外周血用⁶⁰Coγ射线离体照射2.0Gy,分析非稳定性染色体畸变或用单细胞凝胶电泳分析DNA链断裂水平。结果照射前两组的双着丝粒畸变暴露组较高,照射2.0Gy⁶⁰Coγ射线后观察到的双着丝粒畸变暴露组低于对照组,但两组间差异无统计学意义(U=0.0026、0.0084,P>0.05),三着丝粒畸变在两组间差异具有统计学意义(U=3.1622, 0.001<P<0.002);两组间的"彗星"尾长差异有统计学意义(t=25,P<0.001)。结论低剂量天然放射性钍诱导出职业人员的外周血淋巴细胞染色体畸变和DNA损伤的适应性反应。

英文摘要:

Objective To explore if the occupational exposure to low dose thorium could induce adaptive response in peripheral lymphocytes. Methods 40 individuals, who exposed to thorium and rare earth mixed dust (exposure group) or control in Baotou Steel Plant, were selected, and chromosome aberrations were analyzed. Then the peripheral blood samples were irradiated in vitro with 2 Gy ⁶⁰Coγ-rays, and unstable chromosome aberration or DNA stand breakage analysis using single cell gel electrophoresis was performed. Results The dicentrics before 2Gy exposure in exposure group was higher than that in control (P0.05). But the dicentrics after 2Gy exposure in exposure group was lower than that in control, but not significantly (P>0.05). The tricentrics in exposure group was significantly lower than that in control (U=3.1622,0.001t=25,P<0.001). Conclusions Occupational exposure to low dose thorium could induce the adaptive response on chromosome aberration and DNA strand breakage in peripheral lymphocytes.

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