| 郑晓珂,翟品芳,裴素娟,冯卫生,王继峰,牛建昭,王升启.卷柏水部位对造血系统的辐射防护作用[J].中华放射医学与防护杂志,2008,28(1):35-38 |
| 卷柏水部位对造血系统的辐射防护作用 |
| Radioprotective effect of the water part of Selaginella Tamariscina on hematopoietic system in irradiated mice |
| 投稿时间：2007-04-24 |
| DOI： |
| 中文关键词: 卷柏水部位 细胞周期 细胞凋亡 骨髓细胞 |
| 英文关键词:Water part of Selaginella Tamariscina Cell cycle Apoptosis Bone marrow cell |
| 基金项目:教育部博士点基金资助项目(20050026012,20060026019);河南省高校新世纪优秀人才支持计划(2006HANCET-08) |
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| 中文摘要: |
| 目的 观察卷柏水部位对受γ射线照射小鼠造血系统的辐射防护作用。方法 1KM种小鼠于接受8.0Gy 60Co γ射线照射前1周给药,观察受照射小鼠的30d存活率、死亡动物平均存活时间、受照射小鼠体重变化和外周血白细胞数变化;2KM种小鼠于6.0Gy 60Co γ射线照射前72、48和24 h,以及照射后即刻灌服药物或蒸馏水,观察受照射小鼠骨髓细胞周期及凋亡率的变化。结果 卷柏水部位可明显提高照射后小鼠30 d的存活率、死亡动物平均存活时间和小鼠外周血白细胞数,抑制射线引起的小鼠体重的下降;另外,它还可降低受照射小鼠骨髓细胞G0/G1期细胞百分率,升高其G2/M、S期细胞百分率,并可明显降低其细胞凋亡率。结论 卷柏水部位对照射损伤小鼠的造血系统有一定的辐射防护作用。 |
| 英文摘要: |
| Objective To investigate the protective effects of the water part of Selaginella Tamariscina on hematopoietic system in γ-rays irradiated mice. Methods 1Kunming mice were administered with drugs or water 1 week before exposure to 8.0 Gy 60Co γ-rays, 30 d survival, the average life-span of dead mice, the changes in the mice' weights and the number of WBC after irradiation were recorded. 2 Kunming mice were administered with drugs or water at hours 72, 48, 24 before and immediately after exposure to 6.0 Gy 60Co γ-rays, the changes of apoptosis and cell cycle of bone marrow cell in irradiated mice were recorded. Results The water part of Selaginella Tamariscina could increase significantly the 30 d survival, the average life-span of dead mice and the number of WBC, inhibit the loss of the weight in irradiated mice; decrease the percentages of bone marrow cell in G0 G1 phase, increase the percentages of bone marrow cell in G2 M and S phase, and decrease significantly apoptosis of bone marrow cell in irradiated mice. Conclusions The water part of Selaginella Tamariscina has protective effects on hematopoietic system in irradiated mice. |
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