| 李小东,郭永涛,张遵城,柴树德,郑广钧,董华,冯仲苏.125I粒子植入治疗晚期肺癌的损伤效应与临床处置[J].中华放射医学与防护杂志,2007,27(6):565-568 |
| 125I粒子植入治疗晚期肺癌的损伤效应与临床处置 |
| Noxious damaging effect and clinic management of the 125Iodine seeds implantation treatment on non-small cell lung carcinoma |
| 投稿时间：2007-07-16 |
| DOI： |
| 中文关键词: 125I 粒子 近距离治疗 非小细胞肺癌 损伤效应 |
| 英文关键词:125Iodine seeds Brachytherapy Non small cell lung carcinoma (NSCLC) Noxious damaging effect |
| 基金项目: |
|
| 摘要点击次数: 2732 |
| 全文下载次数: 1975 |
| 中文摘要: |
| 目的 分析、研究和处理125I 粒子植入治疗晚期非小细胞肺癌的损伤效应。方法 对121例确诊的晚期非小细胞肺癌,由放射治疗计划系统(TPS)通过CT影像和纤维支气管镜(FFB)引导植入放射性核素125I 粒子,进行验证和病灶周围重要组织器官(如心脏及脊髓)的受量推算,定期进行复查。结果 CT引导组和FFB组的总有效率分别为96.6%和77.3%;损伤效应发生率分别为56.2%和7.5%,其中CT引导组患者心肺及脊髓的照射剂量为31.0和7.5Gy,明显低于正常组织的耐受剂量,该组患者的早期和放射损伤反应发生率分别为14.6%和1.1%,而FFB组未观察到放射损伤反应发生。结论 粒子植入治疗具有肯定的疗效,但不可避免地存在轻度的、易于处理的和可逆的损伤效应,本研究未观察到严重的放射性肺炎和不可逆的肺纤维化。 |
| 英文摘要: |
| Objective To investigate the damaging effect of the 125Iodine seeds implantation on non-small cell lung carcinoma (NSCLC).Methods Under the system of TPS and CT image and flexible fibre-optic bronchoscopy (FFB) guided, 125Iodine seeds were implanted in 121 patients confirmed NSCLC. And the exposure doses of vitals of focus surroundings, for example; the heart and spinal cord were estimated. The NSCLCs were rechecked after fix period.Results The total efficacy rates of two groups were 96.6% and 90.6% respectively. The incidence rate of damaging effect were 55.1% and 12.5% respectively. The exposure doses of the heart-lung and spinal cord by CT image guided were 31.0 Gy and 7.5 Gy respectively, and they were obvious lower than the tolerated dose of normal organization. The early and late incidence rates of radioactive damaging effect by CT image guided groups were 14.6% and 1.1% respectively. But the incidence rate of radioactive damaging effect in FFB group was not observed.Conclusions The therapy of radioactive 125Iodine seeds implantation is ideal and safe. But the low-grade, easily treated and reversible noxious damaging effects are unavoidably. The therapy dose not induce severe radiation pneumonia and irreversible pulmonary fibrosis. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|