| 封丽,王林超,侯殿俊,程玉峰,黄山英,邓大平.低剂量预照射对荷瘤大鼠抗瘤效果的研究[J].中华放射医学与防护杂志,2007,27(6):543-545 |
| 低剂量预照射对荷瘤大鼠抗瘤效果的研究 |
| Effects of low dose radiation on tumor-bearing mice |
| 投稿时间：2006-08-16 |
| DOI： |
| 中文关键词: 低剂量 局部照射 免疫功能 抑瘤作用 |
| 英文关键词:Low dose Local irradiation Immune funtion Inhibitory effect |
| 基金项目:山东省科技厅攻关项目(2004GGB02092) |
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| 中文摘要: |
| 目的 根据低剂量辐射诱导的兴奋效应,探讨低剂量辐射对荷瘤大鼠肿瘤生长及其局部照射的影响。方法 采用Wistar大鼠右腋前线皮下接种Walker-256肿瘤细胞作为肿瘤模型。在种植肿瘤第4天时联合照射组给予75 mGy X射线全身照射,照后24 h给予10 Gy肿瘤局部照射,用游标卡尺测量肿瘤直径,建立肿瘤生长曲线,同时用流式细胞术检测各组淋巴细胞亚群含量及活性,用ELISA法检测了外周血中细胞因子的含量。结果 同单纯局部照射组相比,联合照射组肿瘤生长速度减慢,肿瘤直径在治疗后不同时间均明显小于荷瘤对照组和单纯局部照射组;联合照射组淋巴细胞亚群含量、细胞因子的含量较单纯局部照射组明显提高,差异有统计学意义(P<0.05)。结论 低剂量预照射可以通过提高机体的免疫系统的功能,增强抑瘤作用并减轻局部照射所致的不良反应。 |
| 英文摘要: |
| Objective To explore the effects of low-dose radiation on tumor-bearing mice and radiotherapy induced by low-dose radiation.Methods Male Wistar mice were implanted with Walker-256 sarcoma cells in the right armpit.On day 4,the mice were given 75 mGy whole_body X-ray radiation. From the fifth day, tumor volume was measured, allowing for the creation of a graph depicting tumor growth. Lymphocytes activity in mice after whole-body X-ray radiation with LDR was determinned by FCM. Cytokines level were also determined by ELISA.Results Compared with the radiotherapy group, tumor growth was significantly slower in the mice pre-exposed to low-dose radiation (P<0.05),after 15 days,the average tumor weight in the mice pre-exposed to low-dose radiation was also significantly lower(P<0.05). Lymphocytes activity and the expression of the CK in mice after whole-body γ-ray radiation with LDR increased significantly.Conclusions Low-dose radiation can markedly improve the immune function of the lymphocyte, inhibit the tumor growth, increase the resistant of the high-dose radiotherapy and enhance the effect of radiotherapy. |
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