| 钟亚华,周云峰,谢丛华,等.42例实体癌脑膜转移的放疗疗效分析[J].中华放射医学与防护杂志,2007,27(5):477-479.ZHONG Ya-hua,ZHOU Yun-feng,XIE Cong-hua,et al.Effecacy of radiotherapy on carcinomatous meningitis in 42 patients[J].Chin J Radiol Med Prot,2007,27(5):477-479 |
| 42例实体癌脑膜转移的放疗疗效分析 |
| Effecacy of radiotherapy on carcinomatous meningitis in 42 patients |
| 投稿时间：2007-01-04 |
| DOI： |
| 中文关键词: 放射治疗 实体癌 脑膜转移 |
| 英文关键词:Radiotherapy Carcinoma Carcinomatous meningitis |
| 基金项目: |
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| 中文摘要: |
| 目的 研究实体癌脑膜转移放射治疗疗效及预后因素。方法 回顾性分析放射治疗42例实体癌脑膜转移患者,均行全脑放射治疗,9例伴脊髓受侵者4例行全脑全脊髓照射,5例行节段性脊髓照射,用COX比例风险回归分析预后因素。结果 45.2%(19/42)患者临床症状改善;35例影像学可评价患者14(40%)例病变缩小;全组患者中位生存时间3.7个月(0.8~32.4个月),单因素分析显示年龄≤60、KPS＞60、乳腺癌患者预后较好。多因素分析发现仅KPS≥60者预后较好。结论 放疗是治疗实体癌脑膜转移有效手段,KPS评分是独立预后因素。 |
| 英文摘要: |
| Objective To investigate the effecacy of radiotherapy on carcinomatous meningitis and observe the factors which influenced prognosis. Methods Forty-two patients with carcinomatous meningitis were involved in the retrospective analysis. All patients received whole brain radiotherapy. Among 9 patients with spine involved, 4 patients received whole spine radiation and 5 patients received focal spine radiation. The prognosis factors were analyzed with Cox regression analysis. Results Clinical improvement was documented in 19 of 42 patients (45.2%). Thirty-five patients had a follow-up CT or MRI. A size reduction of lesions was seen in 14 patients (40%). The medium survival time was 3.7 months (ranging from 0.8 months to 32.4 months). Age(≤60), KPS(＞60) and breast cancer were independent factors significantly associated with longer survival term in the univariate analysis. In a multivariate analysis, only KPS＞60 was confirmed as a positive prognostic factor. Conclusions Radiotherapy is an effective way on carcinomatous meningitis. KPS is an independent prognosis factor. |
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