中华放射医学与防护杂志

邴涛,胡相凯,党秉荣,等.重离子和X射线照射对小鼠骨髓细胞周期分布的影响[J].中华放射医学与防护杂志,2007,27(5):425-426.BING Tao,HU Xiang-kai,DANG Bing-rong,et al.Effects of heavy ions and X-ray irradiations on mice bone marrow cell cycle distribution[J].Chin J Radiol Med Prot,2007,27(5):425-426

重离子和X射线照射对小鼠骨髓细胞周期分布的影响

Effects of heavy ions and X-ray irradiations on mice bone marrow cell cycle distribution

投稿时间：2006-09-20

DOI：

中文关键词: 重离子照射 X射线细胞周期骨髓细胞

英文关键词:Heavy ion irradiation X-ray Cell cycle Bone marrow cell

基金项目:“西部之光”资助项目(XB040602);国家自然科学基金重点资助项目(10335050);甘肃省青年科学基金资助项目(3ES041-A25-025)

作者	单位	E-mail
邴涛	730000 兰州, 中国科学院近代物理研究所
胡相凯	730000 兰州, 中国科学院近代物理研究所
党秉荣	730000 兰州, 中国科学院近代物理研究所	dangbr@impcas.ac.cn
谢漪	730000 兰州, 中国科学院近代物理研究所
荆西刚	730000 兰州, 中国科学院近代物理研究所
李文建	730000 兰州, 中国科学院近代物理研究所

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中文摘要:

目的研究重离子和X射线全身照射小鼠对骨髓细胞周期分布的影响,为面向生物学对象的重离子治疗提供基础数据。方法用X射线和重离子照射BALB/c小鼠后,24 h后制得骨髓细胞,采用PI染色用流式细胞仪测骨髓细胞周期变化。结果照射24 h后,X射线照射的各组骨髓细胞周期分布与对照组差异没有统计学意义;重离子照射组与对照组相比,出现G₁/G₀期和G₂/M期阻滞,与相同剂量X射线照射组相比亦出现G₁/G₀期和G₂/M期阻滞。结论相同剂量的重离子照射较X射线对骨髓细胞的损伤更严重,引发不同的生物学效应。

英文摘要:

Objective To investigate the effects of whole body irradiation with heavy ions and X-ray at different doses on mice bone marrow cell cycle distribution, and to provide the basic data for biological-object-oriented hadrontherapy(OOBH). Methods The BALB/c mice were irradiated with heavy ions and X-ray, and the bone marrow cells were harvested after 24 hours, and then the cell cycle distribution were analyzed by flow cytometry. Results At 24 h after irradiation, bone marrow cell cycle distribution of the X-ray groups were not different from the control. While in the heavy ions irradiation groups, G₁/G₀ phase and G₂/M phase were markedly arrested compared with the control group as well as X-ray irradiation group at the same dose. Conclusions The heavy ions irradiation was more dangerous on the mice bone marrow cells than the X-ray irradiation at the same doses. They induced different relative biological effects.

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