| 沈业寿,郑媛,李赓,等.亮菌多糖抗小鼠辐射损伤作用的研究[J].中华放射医学与防护杂志,2007,27(4):340-342.SHEN Ye-shou,ZHENG Yuan,LI Geng,et al.Study on radioprotective activity in mice of Polysaccharides from Armillariella tabescen[J].Chin J Radiol Med Prot,2007,27(4):340-342 |
| 亮菌多糖抗小鼠辐射损伤作用的研究 |
| Study on radioprotective activity in mice of Polysaccharides from Armillariella tabescen |
| 投稿时间：2006-07-31 |
| DOI： |
| 中文关键词: 亮菌 多糖 辐射损伤 白细胞 免疫器官 |
| 英文关键词:Armillariella tabescens Polysaccharides Radiation damage White blood cell Immune organs |
| 基金项目: |
|
| 摘要点击次数: 3771 |
| 全文下载次数: 2041 |
| 中文摘要: |
| 目的 观察亮菌多糖(ATS)对辐射损伤的保护作用。方法 将小鼠随机分为空白对照组(0.9%生理盐水)、辐射模型组、阳性对照组(参芪片)和ATS多糖不同剂量实验组(80、160和320 mg/kg)。 以γ射线照射小鼠全身,引起辐射损伤后观察各组小鼠30 d存活率、白细胞(WBC)数、精子畸变率、骨髓微核(MN)细胞数、骨髓DNA含量和免疫器官重量及血清和肝组织中的超氧化物歧化酶(SOD)和丙二醛(MDA)含量等。结果 ATS能提高受照小鼠存活率(P<0.05)及SOD活性(P<0.05)、升高WBC数(P<0.05)和骨髓DNA含量(P<0.05),抑制小鼠精子畸变率(P<0.05)和骨髓MN细胞数的增加(P<0.05),并使受照小鼠胸腺、脾脏重量回升(P<0.05),还能增加内源性脾结节数(P<0.05),降低MDA含量。结论 ATS对γ射线所致小鼠辐射损伤有较好的保护作用。 |
| 英文摘要: |
| Objective To explore the protective effect of Armillariella tabescen Sing (ATS) on radiation injury in mice.Methods The mice were divided into six groups randomly, including normal group (0.9% physiological salt solution), radiation model group, positive group (Shenqipian, SQP) and experiment groups of different doses of ATS(80, 160, 320 mg/kg).The model was made in mice by γ-ray. After irradiation, 30 day survival rate were observed. WBC counts, micronucleus(MN) test in mouse bone marrow polychromatic erythrocytes (PCE) and sperms abnormality were detected. The content of deoxyribonucleic acid (DNA) in bone marrow, index of thymus and spleen, superoxide dismulases (SOD) activities and malondialdehyde (MDA) levels in serum and liver were measured. Results ATS could obviously increase the 30 day survival rate,content of DNA in bone marrow (P<0.05), number of the colony forming unit of spleen (CFU-S) (P<0.05) and SOD activities (P<0.05). It markedly resist the decrease of the number of white blood cell (WBC) (P<0.05), weights of thymus and spleen. It also could decrease MDA levels (P<0.05), rate of MN (P<0.05) and sperms abnormality frequency (SF) significantly (P<0.05).Conclusions ATS is effective in protecting the γ-radiation injury in mice. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|