中华放射医学与防护杂志

李剑锋,卜梁,杨帆,等.气管旁植入¹²⁵I粒子对家兔血清炎性反应因子IL-1β、IL-6和TNF-α水平的影响[J].中华放射医学与防护杂志,2007,27(4):337-339.LI Jian-feng,BU Liang,YANG Fan,et al.Influence of ¹²⁵I seeds para-tracheal implantation on serum level of inflammatory cytokines IL-1β,IL-6 and TNF-α in rabbits[J].Chin J Radiol Med Prot,2007,27(4):337-339

气管旁植入¹²⁵I粒子对家兔血清炎性反应因子IL-1β、IL-6和TNF-α水平的影响

Influence of ¹²⁵I seeds para-tracheal implantation on serum level of inflammatory cytokines IL-1β,IL-6 and TNF-α in rabbits

投稿时间：2007-05-08

DOI：

中文关键词: ¹²⁵I粒子炎性反应因子近距离照射

英文关键词:¹²⁵I seeds Inflammatory cytokine Brachytherapy

基金项目:

作者	单位	E-mail
李剑锋	100034 北京大学人民医院胸外科暨胸部微创治疗中心
卜梁	100034 北京大学人民医院胸外科暨胸部微创治疗中心
杨帆	100034 北京大学人民医院胸外科暨胸部微创治疗中心
周足力	100034 北京大学人民医院胸外科暨胸部微创治疗中心
李运	100034 北京大学人民医院胸外科暨胸部微创治疗中心
赵辉	100034 北京大学人民医院胸外科暨胸部微创治疗中心
王俊	100034 北京大学人民医院胸外科暨胸部微创治疗中心	jwangmd@yahoo.com

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中文摘要:

目的通过测定气管旁植入¹²⁵I放射性粒子后家兔血清炎性反应因子浓度的变化,分析 ¹²⁵I粒子局部近距离照射对全身炎性反应的影响。方法 30只普通级新西兰家兔随机分为5组,其中1、2、3和4组为实验组, 5组为对照组。全麻下于气管和食管之间植入不同活度的¹²⁵I粒子。每只兔植入4枚按巴黎系统分布、活度相同的¹²⁵I粒子。活度范围为11.1~33.3 MBq(0.3~0.9 mCi),实验组D₉₀范围为21.1~139.0 Gy;健康对照组植入模拟假源假照射。手术前、手术后30、60及90 d各抽取耳缘静脉血1次,用ELISA法测定血清炎性反应因子IL-1β、IL-6和TNF-α水平。结果死亡5只,其余兔体重逐渐增加。血清IL-1β,IL-6和TNF-α水平在1、2和3个月末除第2组外均较实验前升高,但差异无统计学意义。结论 ¹²⁵I粒子气管旁植入局部组织间近距离照射不会引起家兔明显的全身炎性不良反应。

英文摘要:

Objective To evaluate the influence of ¹²⁵I seeds para-tracheal implant on serum level of inflammatory cytokines in rabbits.Methods 30 rabbits were randomized to 5 groups, 4 study groups and control group. The activities of seeds in study groups ranged from 11.1 MBq (0.3 mCi) to 33.3 MBq (0.9 mCi), and D₉₀ were 21.1 to 139.0 Gy. The false seeds were used in control group. Four seeds with equal activity were implanted between trachea and esophagus in each rabbit under general anesthesia. The seeds were arranged according to the Paris principle. Serum samples were collected prior to, 30, 60 and 90 days after implantation. IL-1β,IL-6 and TNF-α levels were measured by ELISA. Results All rabbits were healthy and had weight gaining during study period except 5 died. Serum levels of IL-1β,IL-6 and TNF-α at the end of the first, second and third month were all slightly higher than those of pretreatment. However,there was no statistical significance among them except for group 2.Conclusions Interstitial brachytherapy with ¹²⁵I seeds might not significantly produce systematic inflammatory reaction on rabbits.

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