| 武宁,陈光伟,刘永哲,金顺子,刘树铮.低剂量X射线在优化pEgr-IL18-B7.1基因-放疗方案中的作用[J].中华放射医学与防护杂志,2007,27(3):223-225 |
| 低剂量X射线在优化pEgr-IL18-B7.1基因-放疗方案中的作用 |
| Effect of low dose whole-body X-irradiation on the efficacy of pEgr-IL18-B7.1 gene-radiotherapy |
| 投稿时间：2006-04-17 |
| DOI： |
| 中文关键词: 低剂量X射线 pEgr-IL18-B7.1重组质粒 基因-放疗 Lewis肺癌细胞 |
| 英文关键词:Low dose X-rays Recombinant plasmid pEgr-IL18-B7.1 Gene-radiotherapy Lewis lung carcinoma |
| 基金项目:国家自然科学基金资助项目(30100033) |
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| 中文摘要: |
| 目的 观察低剂量X射线全身照射在接种Lewis肺癌小鼠的pEgr-IL18-B7.1基因-放疗中的抑瘤作用。方法 基因-放疗组中小鼠肿瘤局部注射由多聚乙烯亚胺包裹的pEgr-IL18-B7.1重组质粒,分别接受由2 Gy X射线局部照射和0.075 Gy X射线全身照射组合的不同治疗方案,观察各种治疗方案在荷瘤小鼠中的抑瘤作用。结果 与单纯多次大剂量X射线局部照射相比,单次大剂量X射线局部照射后加多次低剂量全身照射在联合pEgr-IL18-B7.1基因治疗中能体现出更为有效的抑制肿瘤生长作用。结论 低剂量X射线全身照射作为一种优化手段,可有效增强pEgr-IL18-B7.1基因-放疗的抑瘤效果。 |
| 英文摘要: |
| Objective To observe the therapeutic effect of whole-body irradiation with low dose X-rays in mice bearing Lewis lung carcinoma under recombinant plasmid pEgr-IL18-B7.1 gene-radiotherapy. Methods The pEgr-IL18-B7.1 recombinant plasmids mediated by polyethylenimine were injected locally into tumors of the mice with gene-radiotherapy,and then the tumors received different therapeutic regimens containing local X-irradiation with 2 Gy and whole-body X-irradiation with 0.075 Gy, respectively. The anti-tumor effects of low dose X-rays in optimizing the protocol of pEgr_IL18_B7.1 gene-radiotherapy on the tumor-bearing mice were observed.Results As compared with repeated high dose local X-irradiation alone,single high dose local X-irradiation in combination with repeated low dose of whole-body X-irradiation showed more significant inhibition of tumor growth under pEgr-IL18-B7.1 gene-radiotherapy.Conclusions Low dose whole-body X-irradiation superimposed upon a local high dose could significantly enhance the anti-tumor effect in the protocol of pEgr-IL18-B7.1 gene-radiotherapy. |
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