| 傅志超,程惠华,赖红斌,林贵山,李东石,原锦.125例胶质瘤术后三维适形放疗临床研究的初步结果[J].中华放射医学与防护杂志,2007,27(2):164-166 |
| 125例胶质瘤术后三维适形放疗临床研究的初步结果 |
| Three dimensional conformal radiotherapy for 125 cases with gliomas postoperation |
| 投稿时间：2006-04-17 |
| DOI： |
| 中文关键词: 胶质瘤/放射疗法 放射治疗 适形 预后 |
| 英文关键词:Glioma/radiotherapy Radiotherapy Conformal Prognosis |
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| 中文摘要: |
| 目的 探讨三维适形放疗在胶质瘤术后放疗的疗效及毒副反应。方法 胶质瘤术后患者125例随机分为适形放疗组和常规放疗组,适形放疗组63例,常规放疗组62例,术后2周至1个月内接受放射治疗,适形放疗组全程采用立体适形放疗,每次剂量2~2.5 Gy,总剂量50~60 Gy,时间4~6周,常规放疗组采用局部双侧平行对穿野或夹角等中心照射,每次剂量1.8~2.0 Gy,总剂量50~60 Gy,时间5~6周;两组病例合并行影响生存时间因素的COX回归;对比两组局部控制率、生存率及毒副反应差别。结果 病理分级、切除方式和照射方式是影响生存的主要因素,三维适形放疗和常规组的1、2、3年局部控制率分别为77.9%、66.5%、57.7%和67.4%、47.9%、37.9%(χ2=4.65,P<0.05),1、2、3年生存率分别是81.0%、71.3%、63.2%和80.6%、58.1%、44.8%(χ2=4.42,P<0.05),脑水肿发生率分别是33.3%、51.6%(χ2=12.09,P=0.001)。结论 胶质瘤术后局部三维适形放射治疗局部控制率及生存率优于常规放疗,不良反应明显少于常规放疗。 |
| 英文摘要: |
| Objective To evaluate the clinical results and side effect of Three dimensional conformal radiotherapy (3DCRT) for gliomas postoperation. Methods From July 2002 to July 2003, 125 patients with gliomas postoperation were randomly divided in three dimensional conformal radiotherapy (3DCRT) and conventional therapy(CT) groups. The 63 patients in 3DCRT group were received three dimensional conformal therapy constantly in 2.0-2.5 Gy/f, 5 fractions a week to a total dose of 50-60 Gy in 5-6 weeks. The 62 patients in CT group were received conventional radiotherapy in 1.8-2.0 Gy/f, 5 fractions a week to a total dose of 50-60 Gy in 4-6 weeks. Radiotherapy starred within 2 weeks to 1 month after surgery. The local control rate, survival rate and side effects were compared in the two groups. Results The 1-,2-and 3-year local control rates were 77.9%,66.5% and 57.7% in 3DCRT group, 67.4%,47.9% and 37.9% in CT group (χ2=4.65,P<0.05). The 1-,2-and 3-year survival rates were 81.0%,71.3% and 63.2% in 3DCRT group, 80.6%,58.1% and 44.8% in CT group (χ2=4.42, P<0.05). The incidence rate of cerebral edema was 33.3% in 3DCRT group and 51.6% in CT group(χ2=12.09,P=0.001). Conclusions The local control rate and survival rate of patients with gliomas postoperation treated by 3DCRT is superior to CT. However, the incidence rate of side effect in 3DCRT group is lower than that in CT group. |
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