中华放射医学与防护杂志

祝淑钗,沈文斌,李任,王玉祥,苏景伟,李娟.三维适形放疗食管癌所致放射性肺炎相关因素分析[J].中华放射医学与防护杂志,2007,27(2):161-163

三维适形放疗食管癌所致放射性肺炎相关因素分析

Radiation-induced pneumonitis in three-dimensional conformal radiotherapy for oesophageal carcinoma

投稿时间：2006-04-04

DOI：

英文关键词:Esophageal carcinoma Radiotherapy Three-dimensional conformal radiotherapy Radiation-induced pneumonitis

基金项目:教育部高等学校青年教师教学科研奖励计划基金资助项目(2001125);河北省自然科学基金资助项目(C2005800802)

作者	单位
祝淑钗	050011 石家庄, 河北医科大学第四医院放射治疗科
沈文斌	050011 石家庄, 河北医科大学第四医院放射治疗科
李任	050011 石家庄, 河北医科大学第四医院放射治疗科
王玉祥	050011 石家庄, 河北医科大学第四医院放射治疗科
苏景伟	050011 石家庄, 河北医科大学第四医院放射治疗科
李娟	050011 石家庄, 河北医科大学第四医院放射治疗科

摘要点击次数: 2616

全文下载次数: 1791

中文摘要:

目的分析三维适形放疗食管癌患者的临床物理参数,为进一步优化食管癌适形放疗计划,减少放射性肺炎的发生提供参考标准。方法回顾性总结55例食管癌患者的三维适形治疗计划及临床资料,并对相关因素进行单因素、多因素的统计分析。结果 55例中发生放射性肺炎12例,其中2级9例,3级3例。与放射性肺炎相关的因素有二程放疗、总剂量、后半程射野数、总射野数、肺V₁₀、肺V₁₅、肺V₂₀、肺V₂₅、肺D_平均、食管GTVV₅₀。Logistic多元回归分析显示二程放疗、后半程射野数、肺V₂₅为放射性肺炎发生的独立影响因素。结论食管癌二程放疗、后半程射野数、肺V₂₅系影响放射性肺炎发生的主要因素。

英文摘要:

Objective To evaluate the clinical factors and physical parameters related to radiation-induced pneumonitis in oesophageal carcinoma treated with three-dimensional conformal radiotherapy (3DCRT). Methods From October 2000 to December 2003, 55 esophageal carcinoma patients were retrospectively reviewed with clinical factors and physical parameters in relation to radiation-induced pneumonitis. Logistic regression model was used to test their relativities. Results According to the RTOG criteria, pneumonitis was observed in 12 patients, the rate of incidence 22%, with 9 in grade Ⅱ, 3 in grade Ⅲ. Secondary-course radiotherapy, total dose, the late-course irradiation beams, total irradiation beams, lungs V₁₀, lungs V₁₅, lungs V₂₀, lungs V₂₅ and lungs D_mean, and oesophageal GTVV₅₀ were significantly correlated with radiation-indueed pneumonitis. Multilogistic regression analysis showed that secondary-course radiotherapy, the late-course irradiation beams and lungs V₂₅ were the independent inducing factors for pneumonitis, Radiation-induced pneumonitis had no significant effect on the survival of esophageal carcinoma. Conclusions There are no significantly difference in the radiation-induced pneumonitis with the two model of total-course 3D-CRT and the secondary-course 3D-CRT. Secondary-course radiotherapy. the late-course irradiation beams and lungs V₂₅ are significantly associated with the pneumonitis in oesophageal carcinoma patients treated with 3D-CRT.

HTML 查看全文查看/发表评论下载PDF阅读器

关闭