| 翟小明,顾科,王建平,张军宁.成人脑恶性胶质瘤术后放疗同步替尼泊甙联合 司莫司汀化疗疗效分析[J].中华放射医学与防护杂志,2007,27(2):152-153 |
| 成人脑恶性胶质瘤术后放疗同步替尼泊甙联合 司莫司汀化疗疗效分析 |
| Effect of postoperative radiotherapy concurrent chemotherapy on adult patients with malignant cerebral gliomas |
| 投稿时间：2006-05-30 |
| DOI： |
| 中文关键词: 脑 恶性胶质瘤 放射治疗 化学治疗 |
| 英文关键词:Brain Malignant glioma Radiotherapy Chemotherapy |
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| 中文摘要: |
| 目的 前瞻性研究成人脑恶性胶质瘤患者术后同步放化疗的疗效。方法 1999年9月至2003年5月收治50例成人脑恶性胶质瘤术后患者,随机分成两组,各25例。1单纯放疗组,给予术后单纯放疗,DT54~60 Gy;2同步放化疗组,给予单纯放疗组相同的放疗方法,同时于DT20 Gy后行同步替尼泊甙(VM-26)联合司莫司汀(Me-CCNU)化疗。结果 成人恶性胶质瘤术后单纯放疗组1、3、5年生存率分别为56%、24%、6%,中位生存期为16个月;术后同步放化疗组1、3、5年生存率分别为72%、48%、20.11%,中位生存期为36个月。同步放化疗组生存率明显优于单纯放疗组(χ2=4.05,P=0.044)。结论 成人恶性胶质瘤患者在手术后适当时机进行同步放化疗可以提高生存率;VM-26联合Me-CCNU是有效的化疗方案。 |
| 英文摘要: |
| Objective To prospectively study the survival of adult patients with malignant cerebral gliomas after postoperative radiochemotherapy. Methods From Sept. 1999 to May 2003, 50 adult postoperative patients with malignant cerebral gliomass were treated and they were divided into two groups, each including 25 cases. One group was irradiated with DT54-60 Gy, the other group was combined with chemotherapy(VM-26 and Me-CCNU) after exposure to DT20 Gy. Results The 1, 3, and 5 year survival rate of the two groups of patients were 56%, 24%, 6% and 72%, 48%,20.11%, respectively(χ2=4.05,P=0.044). And the median survival time was 16 and 36 months, respectively. Conclusions Given concurrent radiochemotherapy postoperatively, the survival rate could be enhanced in adult patients with malignant cerebral gliomas. VM-26 combined with Me-CCNU should be an effective chemotherapeutic scheme. |
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