| 李学源,蒋华勇,刘娟.局部放疗联合89Sr治疗骨转移癌的疗效观察[J].中华放射医学与防护杂志,2006,26(6):601-602,570 |
| 局部放疗联合89Sr治疗骨转移癌的疗效观察 |
| Observing of the effects on combination with local radiotherapy and radio-nuclides 89Sr to treat bone metastasis cancer |
| 投稿时间：2006-04-30 |
| DOI： |
| 中文关键词: 骨转移癌 放疗 89Sr放射性核素 |
| 英文关键词:Bone metastases Radiotherapy 89Sr radionuclides |
| 基金项目: |
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| 中文摘要: |
| 目的 评价局部放疗配合放射性核素89Sr治疗骨转移癌的疗放,分析单纯放疗单纯核素89Sr治疗及联合治疗的副作用。方法 观察60例确诊为骨转移癌的患者,分为3组,每组20例。局部放疗(A组),采用6MV直线加速器外照射给予吸收剂量30～60Gy/2～4周,局部放疗+89Sr治疗(B组),单纯89Sr治疗(C组)放射性核素89Sr静脉内注射3～4mCi。结果 治疗后B组骨痛缓解,原发灶改善明显好于A、C组;新增疼痛部位及转移灶均少于A、C组(P<0.05)。治疗后血液学的毒性3组差异统计学意义(P>0.05)。结论 局部放疗配合89Sr治疗骨转移癌有较好的疗效,提示对单发性骨转移患者的压痛明显部位给予局部外照射止痛效果明显,对多发骨转移且病灶相距较近的给予放疗联合89Sr治疗效果安全可靠,对全身性多发性骨转移者采用单纯放射性核素89Sr治疗对于止痛和控制骨转移有一定疗效。 |
| 英文摘要: |
| Objective To evaluate the effects on local radiotherapy and radio_nuclides 89Sr to treat cancer with bone metastasis, analyze the simple radiotherapy treatment and the treatment of side effects of radio_nuclide 89Sr. Methods 60 patients,who were bone metastasis cancers,divided into 3 groups: local radiotherapy (A group), 6 MV linear accelerator external irradiation dose given 30_60 Gy/2_4 weeks, local radiotherapy and 89Sr treatment (B group), 89Sr treatment (C group), intravenous injection 3_4 mCi. Results After treatment, B group's bone pain was relieved.B group's primary sites was significant improvement than A and C from bone imaging shown,new pains and metastases sites lower than others.There was no significant difference in toxicity of blood among three groups (P>0.05). Conclusions Local radiotherapy combined with 89Sr meght be an effective treatment for bone metastasis cancer.It is suggested that the pain relieve effect of local external radiotherapy on single bone metastasis location was remarkable.It is safe and reliable to perform radiotherapy and 89Sr combination treatment for multiple bone metastasis in close proximity.And it has certain effects to carry out 89Sr treatment for whole-body multiple bone metastases. |
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