| 顾科,张军宁.转移性骨肿瘤放射治疗临床分析[J].中华放射医学与防护杂志,2006,26(6):595-597 |
| 转移性骨肿瘤放射治疗临床分析 |
| Clinical assessment of radiotherapy for cancers with bone metastases |
| 投稿时间：2006-01-10 |
| DOI： |
| 中文关键词: 肿瘤 骨转移 放射治疗 |
| 英文关键词:Carcinoma Bone metastases Radiotherapy |
| 基金项目: |
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| 中文摘要: |
| 目的 分析79例转移性骨肿瘤放射治疗止痛效果及中位生存期。方法 采用6MV和15MVX线照射转移性骨肿瘤79例共141处病灶。常规分割组18例,照射DT40～50Gy/20～25次共4～5周;大分割组61例,照射DT30～36Gy/10～12次共2～2.5周。结果 (1)总的中位生存期为3.81个月。中位生存期单纯骨转移者8.05个月,原发灶已控制者4.29个月,分别显著高于合并内脏转移者的3.10个月(P<0.05)和原发灶未控或不明者的3.31个月(P<0.05);中位生存期单发和多发骨转移者差异无统计学意义(P>0.05)。(2)放射止痛总的有效率为92.90%,常规分割组止痛效果优于大分割组(χ2=12.99,P=0.005),而止痛效果与原发灶是否得到控制、转移是单发还是多发均无关系。(3)放射止痛起效的快慢与单次剂量成正比(χ2=9.55,P=0.002)。结论 放射治疗可作为转移性骨肿瘤的一种主要止痛手段。 |
| 英文摘要: |
| Objective To estimate median survival time (MST) and assess pain-relief effect of radiotherapy for bone metastatic cancers. Methods During the period from July 1999 to June 2003, 79 cases of malignant tumors with 141 bone metastases were treated by 6 or 15 MV X-rays. Of the all cases, 18 cases were irradiated with conventional fraction: 20-25 times of irradiation during 4-5 weeks, 40-50 Gy in total; 61 cases were treated with lower fraction: 10-12 fractions during 2-2.5 weeks, 30-36 Gy in total. Results (1) Overall MST was estimated to be 3.81 months. MSTs of patients with bone metastases only and patients with both internal organ and bone matastases were 8.05 months and 3.10 months, respectively; the difference between the two kinds of patients was statistically significant (P<0.05). MSTs of those cases with primary lesion controlled and those cases with primary lesion uncontrolled or unspecified were 4.29 months and 3.31 months, respectively; the differences between them was statistically significant (P<0.05). However, the difference of MST between cases with single bone metastatic site and multiple bone metastatic sites was not significant (P>0.05). (2) The overall rate of pain-relief with radiotherapy was 92.90%, and not influenced by control of primary lesion, the number of bone metastatic sites, internal organ metastases, and dose fraction. (3) The relief of ostealgia occurred more promptly after irradiation with higher dose per fraction. Conclusions Radiotherapy could not only help to improve survival of bone metastatic carcinomas, but also be used as an effective and efficient treatment of ostealgia. |
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