周志国,高献书,张萍,乔学英,陈坤,杨香然,万钧.食管癌放疗后Cox模型多因素分析[J].中华放射医学与防护杂志,2006,26(5):496-498
食管癌放疗后Cox模型多因素分析
Cox regression analysis of factors related to prognosis of esophageal cancer after radiotherapy
投稿时间:2005-11-10  
DOI:
中文关键词:  食管癌  放射治疗  Cox模型  分期
英文关键词:Esophageal cancer  Radiotherapy  Cox proportional hazard model  Stage
基金项目:
作者单位E-mail
周志国 050011 石家庄, 河北医科大学第四医院放疗科 gaoxs@heinfo.net 
高献书 北京大学第一医院  
张萍 050011 石家庄, 河北医科大学第四医院放疗科  
乔学英 050011 石家庄, 河北医科大学第四医院放疗科  
陈坤 050011 石家庄, 河北医科大学第四医院放疗科  
杨香然 050011 石家庄, 河北医科大学第四医院放疗科  
万钧 050011 石家庄, 河北医科大学第四医院放疗科  
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中文摘要:
      目的 利用Cox模型(比例风险模型)多因素分析食管癌放射治疗后与生存和复发相关的预后因素,同时探讨CT分期临床应用的合理性。方法 对有完整CT资料的70例食管癌患者进行回顾性分析,选择CT分期在内的7个可能对预后产生影响的因素进行Cox模型多因素分析。结果 CT分期、病变位置、近期疗效是食管癌放疗后生存率的主要影响因素,年龄、CT分期、病变位置是食管癌放疗后复发的主要影响因素。结论 CT分期在非手术食管癌的治疗中能在一定程度上代替食管癌病理分期,指导临床治疗。
英文摘要:
      Objective To study the prognostic factors in patients with cancer of the esophagus after radiotherapy using Cox proportional hazard model and to evaluate the validity of CT-staging. Methods The clinical data of 70 cases of esophageal cancer treated with radiotherapy were collected, and seven factors including CT-stage were analyzed using Cox proportional hazard model. Results The major significant factors influencing survival rate after radiotherapy were CT-stage, location of tumor and short-term curative effect. The major significant factors influencing relapse after radiotherapy were CT-stage, location of tumor and age. Conclusions CT-staging can substitute for TNM staging in some ways in non-operative treatment for patients with esophageal cancer.
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